Synthesis, characterization, DFT and molecular docking studies for novel 1,5-diphenylpenta-1,4-dien-3-one O-benzyl oximes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01697-0
Abstract: The main objectives of this study are: (a) to synthesize novel 1,5-diphenylpenta-1,4-dien-3-one O-benzyl oximes in an efficient way, (b) to investigate the synthesized molecules computationally via DFT calculations, (c) to compare computationally obtained data with… read more here.
Keywords: part; one benzyl; molecular docking; dien one ... See more keywords
Bioactive α,β-conjugated 3-keto-steroids from the Australian brown alga Cystophora xiphocarpa.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112798
Abstract: As part of our ongoing study of the specialised metabolites present in brown algae belonging to the Cystophora genus, eight new steroids including three pairs of diastereoisomers were isolated from Cystophora xiphocarpa (Harvey) (Sargassacea, Fucales).… read more here.
Keywords: dien; one 16s; dihydroxyergosta dien; cystophora xiphocarpa ... See more keywords
Pentacyclic and hexacyclic cucurbitacins from Elaeocarpuspetiolatus.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.112988
Abstract: Four undescribed cucurbitacins, designated as petiolaticins A-D, and four known cucurbitacins were isolated from the bark and leaves of Elaeocarpus petiolatus (Jack) Wall. Their chemical structures were elucidated based on detailed analyses of the NMR… read more here.
Keywords: petiolaticin; epoxy dihydroxy; dihydroxy cucurbit; cucurbit dien ... See more keywords
10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00184
Abstract: Uterotrophic effect of 17α-estradiol, the C17 epimer of the main human estrogen 17β-estradiol, was shown to manifest in animal models at doses lower than those necessary for central outcome raising concerns about its potential to… read more here.
Keywords: estradiol; producing estradiol; dihydroxyestra dien; bioprecursor prodrug ... See more keywords
The Reaction of 6-(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methylcyclohexa-2,4-dien-1-one with Benzene-1,2-diamine: Synthesis and Chemistry of N-(2-Aminophenyl)-2-hydroxy-5-methylbenzimidoyl Cyanide
Sign Up to like & getrecommendations! Published in 2019 at "Synlett"
DOI: 10.1055/s-0039-1690246
Abstract: (Z)-6-(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methylcyclohexa-2,4-dien-1-one, readily prepared from 4,5-dichloro-1,3,4-dithiazolium chloride and p-cresol, reacts with benzene-1,2-diamine to give N-(2-aminophenyl)-2-hydroxy-5-methylbenzimidoyl cyanide. The latter, in acidic media, cyclizes to give, depending on the reaction conditions, 2-methylbenzofuro[2,3-b]quinoxaline, 2-(1H-benzo[d]imidazol-2-yl)-4-methylphenol or 2-(3-aminoquinoxalin-2-yl)-4-methylphenol. read more here.
Keywords: chloro dithiazol; chemistry; ylidene methylcyclohexa; dien one ... See more keywords
In Vitro Expression of Toll-Like Receptors and Proinflammatory Molecules Induced by Ergosta- 7,22-Dien-3-One Isolated from a Wild Mexican Strain of Ganoderma oerstedii (Agaricomycetes).
Sign Up to like & getrecommendations! Published in 2017 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.v19.i3.20
Abstract: Compounds showing pharmacological activity on the immune system are of interest because of their therapeutic potential in the treatment of many diseases. However, data from primary human immune cells and in vivo studies are limited.… read more here.
Keywords: toll like; ergosta dien; like receptors; dien one ... See more keywords