Ring-opening fluorination of cyclopropylmethanols and cycloprpanecarbardehydes with diethylaminosulfur trifluoride
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152655
Abstract: Abstract The reaction of cyclopropylmethanols bearing aromatic substituents on their cyclopropane rings with diethylaminosulfur trifluoride (DAST) effectively caused ring-opening fluorination to produce homoallylic fluorides. This reaction proceeded via a carbocation intermediate. DAST reacted with cyclopropanecarbaldehydes… read more here.
Keywords: ring opening; fluorination cyclopropylmethanols; diethylaminosulfur trifluoride; cyclopropylmethanols cycloprpanecarbardehydes ... See more keywords
Isolation and Reactions of Imidoyl Fluorides Generated from Oxime Using the Diethylaminosulfur Trifluoride/Tetrahydrofuran (DAST-THF) System.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01063
Abstract: Fluorination of oximes with the relatively mild diethylaminosulfur trifluoride/tetrahydrofuran (DAST-THF) system affords imidoyl fluorides. These compounds were isolated, and their structures were confirmed by X-ray single-crystal structure analysis. Reaction of imidoyl fluorides with various nucleophiles… read more here.
Keywords: system; diethylaminosulfur trifluoride; trifluoride tetrahydrofuran; dast thf ... See more keywords
Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride—Preparation of New Antitumor Ecdysteroid Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073447
Abstract: Fluorine represents a privileged building block in pharmaceutical chemistry. Diethylaminosulfur-trifluoride (DAST) is a reagent commonly used for replacement of alcoholic hydroxyl groups with fluorine and is also known to catalyze water elimination and cyclic Beckmann-rearrangement… read more here.
Keywords: antitumor; diethylaminosulfur trifluoride; oriented synthesis; diversity ... See more keywords