Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23016
Abstract: Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone. Liver cancer creates major carcinogenic death despite recently advanced therapies. Hepatocellular carcinoma (HCC) treatment… read more here.
Keywords: group; pru; prunetin; diethylnitrosamine ... See more keywords
Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice
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DOI: 10.1155/2018/9472939
Abstract: Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous treatment. Given the association… read more here.
Keywords: insulin; den; mice; t1dm ... See more keywords
The effect of capsaicin and diethylnitrosamine on mouse nephrotoxicity, hepatotoxicity and hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Acta Veterinaria Brno"
DOI: 10.2754/avb202089040383
Abstract: Diethylnitrosamine is well known for its toxic and carcinogenic properties affecting mainly liver and kidneys. Capsaicin has been proven in previous years as a promising protective agent against many health problems affecting modern people. In… read more here.
Keywords: diethylnitrosamine; liver; effect capsaicin; cancer ... See more keywords
Effect of thymoquinone administration on erythrocyte fragility in diethylnitrosamine administered rats
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DOI: 10.3233/jcb-179008
Abstract: BACKGROUND: Diethylnitrosamine is a carcinogenic chemical found in food unintendedly and also in different media such as cosmetics. Nigella sativa plant has anti-tumoral, anti-inflammatory and anti-diabetic activities. OBJECTIVE: Aim of this study is to investigate… read more here.
Keywords: erythrocyte fragility; diethylnitrosamine administered; thymoquinone; group ... See more keywords
Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21010252
Abstract: The tumor inhibitory potential of the highly active chemerin-156 isoform was described in orthotopic models of hepatocellular carcinoma (HCC). The majority of HCC arises in the fibrotic liver, which was not reproduced in these studies.… read more here.
Keywords: hepatocellular carcinoma; aav; chemerin 156; chemerin ... See more keywords