Difelikefalin for the treatment of moderate-to-severe pruritus associated with chronic kidney disease on hemodialysis
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2023.2197209
Abstract: ABSTRACT Introduction Chronic kidney disease-associated pruritus (CKD-aP) is often experienced by patients with CKD receiving dialysis. Approximately 40% of hemodialysis patients are ‘moderately’ to ‘extremely bothered’ by itching, associated with reduced quality of life, poor… read more here.
Keywords: difelikefalin treatment; chronic kidney; treatment; kidney disease ... See more keywords
Evaluation of the abuse potential of difelikefalin, a selective kappa-opioid receptor agonist, in recreational polydrug users.
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DOI: 10.1111/cts.13173
Abstract: Difelikefalin, a selective kappa-opioid receptor agonist with limited central nervous system penetration, is being developed for the treatment of chronic pruritic conditions. This randomized, double-blind, active- and placebo-controlled, four-way crossover study was designed to evaluate… read more here.
Keywords: opioid receptor; difelikefalin; receptor agonist; potential difelikefalin ... See more keywords
Difelikefalin: A New κ-Opioid Receptor Agonist for the Treatment of Hemodialysis-Dependent Chronic Kidney Disease–Associated Pruritus
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DOI: 10.1177/10600280221115889
Abstract: Objective: To review data for difelikefalin (Korsuva) intravenous solution for management of moderate-to-severe pruritus in hemodialysis (HD) patients. Data Sources: Literature search of PubMed (January 1946-May 2022) and SCOPUS (January 1946-May 2022) was performed using… read more here.
Keywords: opioid receptor; receptor agonist; chronic kidney; kidney disease ... See more keywords
Difelikefalin in the Treatment of Chronic Kidney Disease-Associated Pruritus: A Systematic Review
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DOI: 10.3390/ph15080934
Abstract: Chronic kidney disease-associated pruritus (CKD-aP) is a chronic condition that significantly reduces the quality of life of patients with end-stage renal disease. The etiology is not fully understood, but imbalance in the activity of the… read more here.
Keywords: disease; chronic kidney; treatment; kidney disease ... See more keywords