Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives.
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DOI: 10.1021/acs.biochem.2c00211
Abstract: Sirtuins are protein deacylases regulating metabolism and stress responses and implicated in aging-related diseases. Modulators of the human sirtuins 1-7 are sought as chemical tools and potential therapeutics, for example, for treatment of cancer. We… read more here.
Keywords: mercapto; aryl mercapto; make difference; difference sirt2 ... See more keywords