Divergent Synthesis of Pentacyclic Isoindolinones Enabled by Sequential Insertion of Two Different Isocyanides and Acid Promoted Cyclization of Ketenimines.
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DOI: 10.1021/acs.orglett.3c00393
Abstract: A palladium-catalyzed multicomponent reaction involving o-bromobenzaldehydes and two different isocyanides was developed to assemble series of isoindolinones with spiroindolenine or azepinoindole skeletons. This sequential insertion reaction features mild conditions, a wide substrate scope, and high… read more here.
Keywords: synthesis pentacyclic; two different; sequential insertion; different isocyanides ... See more keywords