Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation.
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DOI: 10.1021/acschembio.7b00485
Abstract: Proteolysis targeting chimera (PROTAC) technology, the recruitment of E3 ubiquitin ligases to induce the degradation of a protein target, is rapidly impacting chemical biology, as well as modern drug development. Here, we explore the universality… read more here.
Keywords: degradation; ligases small; small molecule; different ligases ... See more keywords