Substrate engineering: Effects of different N-protecting groups in the CAL-B-catalysed asymmetric O-acylation of 1-hydroxymethyl-tetrahydro-β-carbolines
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DOI: 10.1016/j.tet.2018.04.012
Abstract: Abstract In the frame of substrate engineering, the steric effect of different N-protecting groups on the enantioselectivity and reaction rate of CAL-B-catalysed (S)-selective O-acylation of N-protected 1-hydroxymethyl-tetrahydro-β-carbolines was investigated. Excellent enantioselectivities (E > 200) were observed when… read more here.
Keywords: acylation; protecting groups; different protecting; substrate engineering ... See more keywords