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Testing for differential abundance in mass cytometry data

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0 Published in 2017 at "Nature methods"

DOI: 10.1038/nmeth.4295

Abstract: When comparing biological conditions using mass cytometry data, a key challenge is to identify cellular populations that change in abundance. Here, we present a computational strategy for detecting 'differentially abundant' populations by assigning cells to… read more here.

Keywords: differential abundance; abundance; cytometry data; mass cytometry ... See more keywords

A novel normalization and differential abundance test framework for microbiome data

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0 Published in 2020 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaa255

Abstract: MOTIVATION Microbial communities have been proved to have close relationship with many diseases. The identification of differentially abundant microbial species is clinically meaningful for finding disease-related pathogenic or probiotic bacteria. However, certain characteristics of microbiome… read more here.

Keywords: framework; abundance; size; microbiome data ... See more keywords

Investigating differential abundance methods in microbiome data: A benchmark study

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1 Published in 2022 at "PLoS Computational Biology"

DOI: 10.1371/journal.pcbi.1010467

Abstract: The development of increasingly efficient and cost-effective high throughput DNA sequencing techniques has enhanced the possibility of studying complex microbial systems. Recently, researchers have shown great interest in studying the microorganisms that characterise different ecological… read more here.

Keywords: sample size; microbiome data; abundance; benchmark ... See more keywords

Identification and Differential Abundance of Mitochondrial Genome Encoding Small RNAs (mitosRNA) in Breast Muscles of Modern Broilers and Unselected Chicken Breed

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1 Published in 2017 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2017.00816

Abstract: Background: Although small non-coding RNAs are mostly encoded by the nuclear genome, thousands of small non-coding RNAs encoded by the mitochondrial genome, termed as mitosRNAs were recently reported in human, mouse and trout. In this… read more here.

Keywords: mitochondrial genome; differential abundance; breast; breast muscles ... See more keywords

A Review on Differential Abundance Analysis Methods for Mass Spectrometry-Based Metabolomic Data

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1 Published in 2022 at "Metabolites"

DOI: 10.3390/metabo12040305

Abstract: This review presents an overview of the statistical methods on differential abundance (DA) analysis for mass spectrometry (MS)-based metabolomic data. MS has been widely used for metabolomic abundance profiling in biological samples. The high-throughput data… read more here.

Keywords: metabolomic data; mass spectrometry; analysis; abundance analysis ... See more keywords