FreeHi-C Spike-in Simulations for Benchmarking Differential Chromatin Interaction Detection.
Sign Up to like & getrecommendations! Published in 2020 at "Methods"
DOI: 10.1016/j.ymeth.2020.07.001
Abstract: High-throughput genome-wide chromatin conformation capture assay (Hi-C) is routinely used to profile long-range genomic interactions and three-dimensional organization of genomes. A key application of Hi-C is the comparative analysis of genomic interactions across different time… read more here.
Keywords: interaction detection; chromatin; chromatin interaction; differential chromatin ... See more keywords
Fast detection of differential chromatin domains with SCIDDO
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa960
Abstract: Abstract Motivation The generation of genome-wide maps of histone modifications using chromatin immunoprecipitation sequencing is a standard approach to dissect the complexity of the epigenome. Interpretation and differential analysis of histone datasets remains challenging due… read more here.
Keywords: chromatin domains; chromatin; analysis; differential chromatin ... See more keywords
FIND: difFerential chromatin INteractions Detection using a spatial Poisson process.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.212241.116
Abstract: Polymer-based simulations and experimental studies indicate the existence of a spatial dependency between the adjacent DNA fibers involved in the formation of chromatin loops. However, the existing strategies for detecting differential chromatin interactions assume that… read more here.
Keywords: chromatin interactions; chromatin; spatial poisson; differential chromatin ... See more keywords