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Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.07.008
Abstract: Aldose reductase (AKR1B1), the key enzyme of the polyol pathway, plays a crucial role in the development of long-term complications affecting diabetic patients. Nevertheless, the expedience of inhibiting this enzyme to treat diabetic complications has…
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Keywords:
reductase;
differential inhibitors;
aldose reductase;
pyrazolo pyrimidine ... See more keywords
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Published in 2022 at "Biology"
DOI: 10.3390/biology11091324
Abstract: Simple Summary The increased glucose levels occurring in diabetes lead to several metabolic alterations responsible for the onset of the so-called diabetic complications, which include nephropathies, neuropathies, retinopathies, and cataract. An increased flux of glucose…
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Keywords:
aldose reductase;
activity;
action;
reductase differential ... See more keywords
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Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12040485
Abstract: Aldose reductase, classified within the aldo-keto reductase family as AKR1B1, is an NADPH dependent enzyme that catalyzes the reduction of hydrophilic as well as hydrophobic aldehydes. AKR1B1 is the first enzyme of the so-called polyol…
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Keywords:
inhibitors aldose;
aldose reductase;
enzyme;
search differential ... See more keywords