Development of Differential Ion Mobility Spectrometry Based Tandem Devices for Ion Separation Prior to Mass Spectrometry Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.10099
Abstract: Differential ion mobility spectrometry (DMS) provides distinct potential in separation of gas phase ions. However, the resolving power still limits the widespread application of DMS technology and inspires to design tandem DMS for improvement of… read more here.
Keywords: differential ion; spectrometry; mass spectrometry; ion ... See more keywords
Differential Ion Mobility Separations of d/l Peptide Epimers.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c05023
Abstract: Life was originally assumed to utilize the l-amino acids only. Since 1980s, the d-amino acid-containing peptides (DAACPs) were detected in animals, often at extremely low levels with tremendous functional specificity. As the unguided proteomic algorithms… read more here.
Keywords: separations peptide; differential ion; ion mobility; mobility separations ... See more keywords
Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells.
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DOI: 10.1021/acs.analchem.2c02056
Abstract: The sensitivity and depth of proteomic analyses are limited by isobaric ions and interferences that preclude the identification of low abundance peptides. Extensive sample fractionation is often required to extend proteome coverage when sample amount… read more here.
Keywords: proteogenomics differential; ion mobility; differential ion; cancer ... See more keywords
Characterization of Complete Histone Tail Proteoforms Using Differential Ion Mobility Spectrometry
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DOI: 10.1021/acs.analchem.7b00379
Abstract: Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperatively modulate the chromatin structure and function. Nearly all functional PTMs are found on the N-terminal histone domains (tails) of ∼50 residues protruding from the… read more here.
Keywords: ion mobility; mobility spectrometry; histone; differential ion ... See more keywords