An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10487-4
Abstract: Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of… read more here.
Keywords: homeostasis; methylation; cross omics; differential methylation ... See more keywords
A survey of the approaches for identifying differential methylation using bisulfite sequencing data
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbx013
Abstract: &NA; DNA methylation is an important epigenetic mechanism that plays a crucial role in cellular regulatory systems. Recent advancements in sequencing technologies now enable us to generate highâthroughput methylation data and to measure methylation up… read more here.
Keywords: methylation; methylation using; survey; differential methylation ... See more keywords
Differential methylation affects risk of MS
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.361.6399.241-e
Abstract: DNA Methylation Specific variants of the human leukocyte antigen (HLA) locus are heritable risk factors for the autoimmune disease multiple sclerosis (MS). However, how these variants confer risk is not well understood. It has been… read more here.
Keywords: differential methylation; methylation; affects risk; methylation affects ... See more keywords
The Epigenetics of Psychosis: A Structured Review with Representative Loci
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030561
Abstract: The evidence for an environmental component in chronic psychotic disorders is strong and research on the epigenetic manifestations of these environmental impacts has commenced in earnest. In reviewing this research, the focus is on three… read more here.
Keywords: methylation; epigenetics psychosis; psychotic disorders; psychosis structured ... See more keywords
Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications for Pathogenic Mechanism and Drug Targeting
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12121898
Abstract: Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease with genomic and non-genomic contributions to risk. We hypothesize that epigenetic factors are a significant contributor to SLE risk and may be informative for… read more here.
Keywords: acid sensing; nucleic acid; lupus; differential methylation ... See more keywords
Assessing the Differential Methylation Analysis Quality for Microarray and NGS Platforms
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108591
Abstract: Differential methylation (DM) is actively recruited in different types of fundamental and translational studies. Currently, microarray- and NGS-based approaches for methylation analysis are the most widely used with multiple statistical models designed to extract differential… read more here.
Keywords: methylation; microarray ngs; quality; methylation analysis ... See more keywords