Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2022.02.001
Abstract: Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs), the… read more here.
Keywords: response; vascular tone; nitric oxide; differential phosphorylation ... See more keywords
Differential phosphorylation of Clr4SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202255928
Abstract: Methylation of histone H3 at lysine 9 (H3K9) is a hallmark of heterochromatin that plays crucial roles in gene silencing, genome stability, and chromosome segregation. In Schizosaccharomyces pombe, Clr4 mediates both di‐ and tri‐methylation of… read more here.
Keywords: h3k9 methylation; methylation; methylation switch; differential phosphorylation ... See more keywords