Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01497-8
Abstract: The transcription factor FOXG1 serves pleiotropic functions in brain development ranging from the regulation of precursor proliferation to the control of cortical circuit formation. Loss-of-function mutations and duplications of FOXG1 are associated with neurodevelopmental disorders… read more here.
Keywords: adult neurogenic; foxg1 dosage; differential vulnerability; neurogenic niches ... See more keywords
Differential vulnerability of locus coeruleus and dorsal raphe neurons to chronic methamphetamine-induced degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.949923
Abstract: Methamphetamine (meth) increases monoamine oxidase (MAO)-dependent mitochondrial stress in axons of substantia nigra pars compacta (SNc), and ventral tegmental area (VTA) dopamine neurons. Chronic administration of meth results in SNc degeneration and MAO inhibition is… read more here.
Keywords: stress; degeneration; dependent mitochondrial; neurons chronic ... See more keywords
Genetic Markers of Differential Vulnerability to Sleep Loss in Adults
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12091317
Abstract: In this review, we discuss reports of genotype-dependent interindividual differences in phenotypic neurobehavioral responses to total sleep deprivation or sleep restriction. We highlight the importance of using the candidate gene approach to further elucidate differential… read more here.
Keywords: sleep loss; vulnerability; genetic markers; differential vulnerability ... See more keywords