Four differentially methylated gene pairs to predict the prognosis for early stage hepatocellular carcinoma patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26256
Abstract: Hepatocellular carcinoma (HCC) was the second most common malignant tumor with a poor prognostic condition. We aimed to identify novel methylation signatures to predict HCC patients at their early stages. Differentially expressed methylated genes between… read more here.
Keywords: hepatocellular carcinoma; hcc; hcc patients; differentially methylated ... See more keywords
Multi-network approach to identify differentially methylated gene communities in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.007
Abstract: BACKGROUND AND OBJECTIVE High-throughput Next Generation Sequencing tools have generated immense quantity of genome-wide methylation and expression profiling data, resulting in an unprecedented opportunity to unravel the epigenetic regulatory mechanisms underlying cancer. Identifying differentially methylated… read more here.
Keywords: differentially methylated; gene communities; cancer; gene ... See more keywords
Obese status is associated with accelerated DNA methylation change in peripheral blood of senior dogs.
Sign Up to like & getrecommendations! Published in 2021 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2021.07.024
Abstract: Obesity and its associated comorbidities constitute a major and growing health problem worldwide not only involved with people but also dogs and cats. Although few genetic mutations have been associated with obesity in dogs, molecular… read more here.
Keywords: methylation; cpg sites; change; differentially methylated ... See more keywords
Identification of differentially methylated cell-types in Epigenome-Wide Association Studies
Sign Up to like & getrecommendations! Published in 2018 at "Nature methods"
DOI: 10.1038/s41592-018-0213-x
Abstract: An outstanding challenge of epigenome-wide association studies (EWASs) performed in complex tissues is the identification of the specific cell type(s) responsible for the observed differential DNA methylation. Here we present a statistical algorithm called CellDMC… read more here.
Keywords: methylation; differentially methylated; cell; epigenome wide ... See more keywords
Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical science"
DOI: 10.1042/cs20220644
Abstract: Pre-eclampsia (PE) is a major hypertensive disorder of pregnancy. Widespread differentially methylated cytosines (DMCs) with modest changes in methylation level are associated with PE, whereas their cause and biological significance remain unknown. We aimed to… read more here.
Keywords: methylation; dna methylation; methylated cytosines; pre eclampsia ... See more keywords
Accounting for differential variability in detecting differentially methylated regions
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbx097
Abstract: Abstract DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA… read more here.
Keywords: methylation; differential variability; new method; differentially methylated ... See more keywords
Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
Sign Up to like & getrecommendations! Published in 2022 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000001147
Abstract: ABSTRACT Objective Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among… read more here.
Keywords: significantly differentially; optimism; epigenome wide; dna methylation ... See more keywords
Genome-wide DNA methylation profiles of autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2022 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000314
Abstract: Objectives We aimed to identify differentially methylated genes and related signaling pathways in autism spectrum disorder (ASD). Methods First, the DNA methylation profile in the brain samples (GSE131706 and GSE80017) and peripheral blood samples (GSE109905)… read more here.
Keywords: methylated genes; autism spectrum; dna methylation; spectrum disorder ... See more keywords
A hidden markov model for identifying differentially methylated sites in bisulfite sequencing data.
Sign Up to like & getrecommendations! Published in 2019 at "Biometrics"
DOI: 10.1111/biom.12965
Abstract: DNA methylation studies have enabled researchers to understand methylation patterns and their regulatory roles in biological processes and disease. However, only a limited number of statistical approaches have been developed to provide formal quantitative analysis.… read more here.
Keywords: hidden markov; methylation; sequencing data; bisulfite sequencing ... See more keywords
A Bayesian hidden Markov model for detecting differentially methylated regions.
Sign Up to like & getrecommendations! Published in 2018 at "Biometrics"
DOI: 10.1111/biom.13000
Abstract: Alterations in DNA methylation have been linked to the development and progression of many diseases. The bisulfite sequencing technique presents methylation profiles at base resolution. Count data on methylated and unmethylated reads provide information on… read more here.
Keywords: hidden markov; methylation; differentially methylated; markov model ... See more keywords
Identification of Methylated Gene Biomarkers in Patients with Alzheimer's Disease Based on Machine Learning
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/8348147
Abstract: Background Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the cognitive impairments. It is essential to identify potential gene biomarkers for AD pathology. Methods DNA methylation expression data of patients with AD were… read more here.
Keywords: methylated sites; alzheimer disease; gene biomarkers; differentially methylated ... See more keywords