Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22227
Abstract: Biobanks of human biosamples and cell lines are indispensable for biomedical research on human health and disease and for drug development projects. Many human cell line biobanks worldwide hold collections of lymphoblastoid cell lines (LCLs),… read more here.
Keywords: ipsc research; human cells; research; drug development ... See more keywords
Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-021-02303-5
Abstract: Human induced pluripotent stem cells (hiPSCs) have revolutionized the generation of experimental disease models, but the development of protocols for the differentiation of functionally active neuronal subtypes with defined specification is still in its infancy.… read more here.
Keywords: serotonin specific; differentiated human; neurons differentiated; specific neurons ... See more keywords
Cytotoxicity induced by three commercial neonicotinoid insecticide formulations in differentiated human neuroblastoma SH-SY5Y cells.
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology research"
DOI: 10.1093/toxres/tfae171
Abstract: Background Neonicotinoid insecticides are used worldwide for crop protection. They act as agonists at postsynaptic nicotinic acetylcholine receptors (nAChRs), disrupting normal neurotransmission in target insects. Human exposure is high due to the widespread use of… read more here.
Keywords: human neuroblastoma; cytotoxicity; differentiated human; neuroblastoma sy5y ... See more keywords
Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-025-01159-1
Abstract: The airway epithelium represents the first line of defense of the lungs, functioning both as a physical barrier as well as an active immune modulator. However, in the last years, pneumonia caused by the opportunistic… read more here.
Keywords: acinetobacter baumannii; response; goblet cell; human bronchial ... See more keywords
Ellagic Acid Triggers the Necrosis of Differentiated Human Enterocytes Exposed to 3-Nitro-Tyrosine: An MS-Based Proteomic Study
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122485
Abstract: To study the molecular basis of the toxicological effect of a dietary nitrosated amino acid, namely, 3-nitrotyrosine (3-NT), differentiated human enterocytes were exposed to dietary concentrations of this species (200 μM) and analyzed for flow… read more here.
Keywords: human enterocytes; enterocytes exposed; acid; ellagic acid ... See more keywords