33 LANDSCAPE OF ALLELE-SPECIFIC OPEN CHROMATIN IN HUMAN IPSC-DIFFERENTIATED NEURONS AND IT IMPLICATION FOR MENTAL DISORDERS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.034
Abstract: Background Allelic Imbalance of gene Expression (AIE) plays important role during neurodevelopment. However, the underlying mechanism of AIE has not been fully understood. Since chromatin accessibility (openness) has a strong influence on gene transcription, we… read more here.
Keywords: chromatin; open chromatin; specific open; allele specific ... See more keywords
Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins
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DOI: 10.3390/brainsci13050728
Abstract: Organophosphate (OP) and carbamate pesticides are toxic to pests through targeted inhibition of acetylcholinesterase (AChE). However, OPs and carbamates may be harmful to non-target species including humans and could induce developmental neurotoxicity if differentiated or… read more here.
Keywords: concentration; organophosphate carbamate; neurotoxicity; differentiated neurons ... See more keywords