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   Articles with "differentiation" as a keyword



Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13963

Abstract: Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid… read more here.

Keywords: osteoclast differentiation; differentiation; bone loss; related protein ... See more keywords

EZH2 modulates retinoic acid signaling to ensure myotube formation during development

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14334

Abstract: Sequential differentiation of presomitic progenitors into myocytes and subsequently into myotubes and myofibers is essential for the myogenic differentiation program (MDP) crucial for muscle development. Signaling factors involved in MDP are polycomb repressive complex 2… read more here.

Keywords: myocyte differentiation; development; retinoic acid; differentiation ... See more keywords

Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF‐β/SMAD2/3 pathway

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recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14862

Abstract: Chondrocyte differentiation is crucial for cartilage formation. However, the complex processes and mechanisms coordinating chondrocyte proliferation and differentiation remain incompletely understood. Here, we report a novel function of the adaptor protein Gulp1 in chondrocyte differentiation.… read more here.

Keywords: differentiation; smad2 pathway; tgf smad2; gulp1 ... See more keywords

KIF5A upregulation by FAK-mediated downregulation of epigenetic modifiers promotes mitochondrial dynamics in neuronal differentiation.

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recommendations! Published in 2025 at "FEBS letters"

DOI: 10.1002/1873-3468.70177

Abstract: Neuronal differentiation depends on mitochondrial transport and networking toward the developing axon and dendrites. Herein, we report that the motor protein kinesin family member 5A (KIF5A) is essential for neuronal maturation through regulation of mitochondrial… read more here.

Keywords: differentiation; downregulation epigenetic; epigenetic modifiers; fak ... See more keywords

Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12614

Abstract: Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene expression studies in acute promyelocytic leukemia (APL)… read more here.

Keywords: atra induced; isgylation; apl cells; expression ... See more keywords

ADAMTS7 degrades Comp to fuel BMP2‐dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12939

Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with a high metastatic potential. Despite dramatic changes in OS treatments over the past decades, their efficiency still remains limited, with… read more here.

Keywords: adamts7 degrades; differentiation; osteogenic differentiation; comp fuel ... See more keywords
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MiR‐17‐3p inhibits osteoblast differentiation by downregulating Sox6 expression

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12979

Abstract: Osteoporosis and osteoarthritis are orthopedic disorders that affect millions of elderly people worldwide; stimulation of bone formation is a potential therapeutic strategy for the treatment of these conditions. As the only bone‐forming cells, osteoblasts play… read more here.

Keywords: mir; differentiation; role; osteoblast differentiation ... See more keywords
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Differentiation between thyroid‐associated orbitopathy and Graves’ disease by iTRAQ‐based quantitative proteomic analysis

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recommendations! Published in 2021 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13172

Abstract: Graves’ ophthalmopathy, also known as thyroid‐associated orbitopathy (TAO), is the most common inflammatory eye disease in adults. The most common etiology for TAO is Graves’ disease (GD); however, proteomic research focusing on differences between GD… read more here.

Keywords: tao; thyroid associated; associated orbitopathy; differentiation ... See more keywords

KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA‐Seq and scRNA‐Seq data

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13446

Abstract: Klinefelter syndrome (KS) is a leading contributor to male infertility and is characterised by complex and diverse clinical features; however, genetic changes in the KS transcriptome remain largely unknown. We therefore used transcriptomic and single‐cell… read more here.

Keywords: cell; scrna seq; seq; klinefelter syndrome ... See more keywords

Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1‐mediated deSUMOylation of SIRT3

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13539

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are capable of multidirectional differentiation, and engrafted BMSCs can be used to replace damaged chondrocytes for treatment of intervertebral disc disease. However, chondroblast differentiation of implanted BMSCs is inhibited… read more here.

Keywords: sirt3; leptin; senp1; bmscs ... See more keywords

Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13652

Abstract: Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin-like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression,… read more here.

Keywords: bone; kielin chordin; bone morphogenetic; differentiation ... See more keywords