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   Articles with "differentiation" as a keyword



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Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13963

Abstract: Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid… read more here.

Keywords: osteoclast differentiation; differentiation; bone loss; related protein ... See more keywords
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EZH2 modulates retinoic acid signaling to ensure myotube formation during development

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14334

Abstract: Sequential differentiation of presomitic progenitors into myocytes and subsequently into myotubes and myofibers is essential for the myogenic differentiation program (MDP) crucial for muscle development. Signaling factors involved in MDP are polycomb repressive complex 2… read more here.

Keywords: myocyte differentiation; development; retinoic acid; differentiation ... See more keywords
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Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12614

Abstract: Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene expression studies in acute promyelocytic leukemia (APL)… read more here.

Keywords: atra induced; isgylation; apl cells; expression ... See more keywords
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ADAMTS7 degrades Comp to fuel BMP2‐dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12939

Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with a high metastatic potential. Despite dramatic changes in OS treatments over the past decades, their efficiency still remains limited, with… read more here.

Keywords: adamts7 degrades; differentiation; osteogenic differentiation; comp fuel ... See more keywords
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MiR‐17‐3p inhibits osteoblast differentiation by downregulating Sox6 expression

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12979

Abstract: Osteoporosis and osteoarthritis are orthopedic disorders that affect millions of elderly people worldwide; stimulation of bone formation is a potential therapeutic strategy for the treatment of these conditions. As the only bone‐forming cells, osteoblasts play… read more here.

Keywords: mir; differentiation; role; osteoblast differentiation ... See more keywords
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Differentiation between thyroid‐associated orbitopathy and Graves’ disease by iTRAQ‐based quantitative proteomic analysis

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recommendations! Published in 2021 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13172

Abstract: Graves’ ophthalmopathy, also known as thyroid‐associated orbitopathy (TAO), is the most common inflammatory eye disease in adults. The most common etiology for TAO is Graves’ disease (GD); however, proteomic research focusing on differences between GD… read more here.

Keywords: tao; thyroid associated; associated orbitopathy; differentiation ... See more keywords
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KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA‐Seq and scRNA‐Seq data

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13446

Abstract: Klinefelter syndrome (KS) is a leading contributor to male infertility and is characterised by complex and diverse clinical features; however, genetic changes in the KS transcriptome remain largely unknown. We therefore used transcriptomic and single‐cell… read more here.

Keywords: cell; scrna seq; seq; klinefelter syndrome ... See more keywords

Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1‐mediated deSUMOylation of SIRT3

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13539

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are capable of multidirectional differentiation, and engrafted BMSCs can be used to replace damaged chondrocytes for treatment of intervertebral disc disease. However, chondroblast differentiation of implanted BMSCs is inhibited… read more here.

Keywords: sirt3; leptin; senp1; bmscs ... See more keywords
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Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13652

Abstract: Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin-like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression,… read more here.

Keywords: bone; kielin chordin; bone morphogenetic; differentiation ... See more keywords
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Efficient Single‐Dose Induction of Osteogenic Differentiation of Stem Cells Using Multi‐Bioactive Hybrid Nanocarriers

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recommendations! Published in 2020 at "Advanced Biosystems"

DOI: 10.1002/adbi.202000123

Abstract: Bone regeneration requires the presence of specific factors to induce the differentiation of stem cells into osteoblasts. These factors induce osteogenesis by stimulating the expression of bone‐related proteins, bone cell proliferation and differentiation. Herein, bioactive… read more here.

Keywords: stem cells; differentiation; differentiation stem; osteogenic differentiation ... See more keywords
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A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

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recommendations! Published in 2017 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201703569

Abstract: Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges… read more here.

Keywords: osteoblast differentiation; groove pattern; differentiation; groove patterns ... See more keywords