Melanoma Differentiation Associated Gene-9/Syndecan Binding Protein (MDA-9/SDCBP) Promotes Hepatocellular Carcinoma (HCC).
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32797
Abstract: The oncogene Melanoma differentiation associated gene-9/syndecan binding protein (MDA-9/SDCBP) is overexpressed in many cancers promoting aggressive, metastatic disease. However, the role of MDA-9 in regulating hepatocellular carcinoma (HCC) has not been well-studied. To unravel the… read more here.
Keywords: alb mda; mda; associated gene; hcc ... See more keywords
BEND3 safeguards pluripotency by repressing differentiation-associated genes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107406119
Abstract: Significance The molecular basis of how the BEN domain–containing gene family regulates chromatin function and transcription remains to be elucidated. We report that BEND3 is highly expressed in pluripotent cells and binds to promoters of… read more here.
Keywords: differentiation; bend3 safeguards; safeguards pluripotency; differentiation associated ... See more keywords
Neuroblast Differentiation-Associated Protein Derived Polypeptides: AHNAK(5758-5775) Induces Inflammation by Activating Mast Cells via ST2
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2151368
Abstract: ABSTRACT Psoriasis is a chronic inflammatory skin disease. Mast cells are significantly increased and activated in psoriatic lesions and are involved in psoriatic inflammation. Some endogenous substances can interact with the surface receptors of mast… read more here.
Keywords: differentiation associated; neuroblast differentiation; mast cells; 5758 5775 ... See more keywords
Longitudinal study of patients with antimelanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated interstitial lung disease.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac525
Abstract: OBJECTIVES To describe the 8-year longitudinal study and long-term prognosis of a large inception cohort of anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (MDA5+) dermatomyositis (DM)-interstitial lung disease (ILD) patients. METHODS 216 patients diagnosed with MDA5+… read more here.
Keywords: long term; lung; differentiation associated; term ... See more keywords
Intravenous immunoglobulin contributes to the control of antimelanoma differentiation‐associated protein 5 antibody‐associated dermatomyositis with palmar violaceous macules/papules
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Dermatology"
DOI: 10.1111/bjd.15499
Abstract: Autoantibodies to melanoma differentiation‐associated protein 5 (MDA5) are associated with a subset of patients with dermatomyositis (DM) who have rapidly progressive interstitial lung disease (RP‐ILD) with poor prognosis. Intensive immunosuppressive therapy is initiated before irreversible… read more here.
Keywords: intravenous immunoglobulin; associated protein; antibody; antibody associated ... See more keywords
Rheumatoid Arthritis Complicated with Anti-melanoma Differentiation-associated Gene 5 Antibody-positive Interstitial Pneumonia
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.1613-18
Abstract: Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We… read more here.
Keywords: antibody; antibody positive; rheumatoid arthritis; differentiation associated ... See more keywords
Systematic Construction and Validation of a Novel Macrophage Differentiation–Associated Prognostic Model for Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.877656
Abstract: Background: Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the human urinary system. Macrophage differentiation is associated with tumorigenesis. Therefore, exploring the prognostic value of macrophage differentiation–associated genes (MDGs) may contribute to… read more here.
Keywords: cell; ccrcc; macrophage differentiation; differentiation associated ... See more keywords
RNA-Containing Immune Complexes Formed by Anti-Melanoma Differentiation Associated Gene 5 Autoantibody Are Potent Inducers of IFN-α
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.743704
Abstract: Objective Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody is a distinctive serology hallmark of dermatomyositis (DM). As an autoantigen, MDA5 is a cytoplasmic RNA recognition receptor. The aim of this study was to address the question… read more here.
Keywords: anti mda5; ifn; differentiation associated; anti melanoma ... See more keywords
Rare complications of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: Time to nip them in the bud
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1009546
Abstract: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (MDA5+ DM) is an infrequent autoimmune disease, which mainly distributes in Asians and females. MDA5+ DM usually presents various skin lesions and positive anti-MDA5 antibody (a myositis-specific autoantibody for… read more here.
Keywords: rare complications; associated gene; differentiation associated; melanoma differentiation ... See more keywords
Pathogenesis of Anti-melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis: A Concise Review With an Emphasis on Type I Interferon System
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.833114
Abstract: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (MDA5+ DM) is typically characterized by cutaneous manifestations, amyopathic or hypomyopathic muscle involvement, and a high incidence of rapid progressive interstitial lung disease (RP-ILD). However, the exact etiology and… read more here.
Keywords: melanoma differentiation; associated gene; differentiation associated; gene ... See more keywords