Differentiation of Induced Pluripotent Stem Cells Into Chondrocytes: Methods and Applications for Disease Modeling and Drug Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4524
Abstract: Induced pluripotent stem cell (iPSC) technology allows pathomechanistic and therapeutic investigation of human heritable disorders affecting tissue types whose collection from patients is difficult or even impossible. Among them are cartilage diseases. Over the past… read more here.
Keywords: pluripotent stem; disease; induced pluripotent; differentiation induced ... See more keywords
IL-3 inhibits rat osteoclast differentiation induced by TNF-α and other pro-osteoclastogenic cytokines.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biosciences"
DOI: 10.1007/s12038-021-00181-3
Abstract: IL-3, a haematopoiesis regulatory factor, has previously been shown to inhibit both mouse and human osteoclast differentiation and bone resorption. Here, the role of rat IL-3 on rat osteoclast differentiation was evaluated to address whether… read more here.
Keywords: osteoclast differentiation; differentiation induced; induced tnf; differentiation ... See more keywords
Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107275
Abstract: Periodontitis is a common chronic disease. Osteoclast differentiation contributes to alveolar bone resorption which is a distinct phenomenon during periodontitis. Syndecan 4 (SDC4), a member of the syndecan family, was found to be highly expressed… read more here.
Keywords: osteoclast differentiation; induced rankl; sdc4; differentiation induced ... See more keywords
Differentiation of Induced Pluripotent Stem Cells towards Mesenchymal Stromal Cells is Hampered by Culture in 3D Hydrogels
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51911-5
Abstract: Directed differentiation of induced pluripotent stem cells (iPSCs) towards specific lineages remains a major challenge in regenerative medicine, while there is a growing perception that this process can be influenced by the three-dimensional environment. In… read more here.
Keywords: differentiation induced; differentiation; pluripotent stem; induced pluripotent ... See more keywords