Oxymatrine possibly inhibits differentiation and maturation of oligodendrocytes in the remyelination of the toxin-induced demyelination animal model
Sign Up to like & getrecommendations! Published in 2025 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-025-01726-3
Abstract: Multiple sclerosis (MS) is characterized by demyelination. In demyelinated MS lesions, the recruitment, differentiation, and maturation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes (OLGs) are inhibited, leading to remyelination failure. Promoting OLG differentiation and maturation… read more here.
Keywords: maturation; model; differentiation maturation; demyelination ... See more keywords
Autophagy-dependent mitochondrial function regulates osteoclast differentiation and maturation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.155
Abstract: Bone homeostasis is maintained by bone remodeling, which involves continuous bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone turnover, caused by osteoclast overactivation, causes destructive bone diseases. However, the mechanisms underlying… read more here.
Keywords: osteoclast differentiation; differentiation maturation; mitochondrial function; bone ... See more keywords
Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.745111
Abstract: NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of NRF2 in human breast cancer (BC) cells.… read more here.
Keywords: nrf2 axis; proliferation; differentiation maturation; fkbp4 nr3c1 ... See more keywords
Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.660644
Abstract: The Bmp2 and Bmp4 expressed in root mesenchyme were essential for the patterning and cellular differentiation of tooth root. The role of the epithelium-derived Bmps in tooth root development, however, had not been reported. In… read more here.
Keywords: bmp2 bmp4; differentiation maturation; root mesenchyme; root ... See more keywords