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   Articles with "differentiation mscs" as a keyword



TNF-α suppresses osteogenic differentiation of MSCs by accelerating P2Y2 receptor in estrogen-deficiency induced osteoporosis.

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recommendations! Published in 2018 at "Bone"

DOI: 10.1016/j.bone.2018.09.012

Abstract: Tumor Necrosis Factor-α (TNF-α)-inhibited osteogenic differentiation of mesenchymal stem cells (MSCs) contributes to impaired bone formation, which plays a central role in the pathogenesis of postmenopausal osteoporosis. However, the exact mechanisms of TNF-α-inhibited osteoblast differentiation… read more here.

Keywords: receptor; p2y2 receptor; tnf; differentiation mscs ... See more keywords

ROS induces CHOP-mediated Akr1A1 gene expression regulating the adipose-osteogenic lineage differentiation of MSCs through the SIRT1-dependent pathway

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recommendations! Published in 2025 at "Physiology"

DOI: 10.1152/physiol.2025.40.s1.0777

Abstract: The Aldo-keto reductase family 1 member A1 (Akr1A1) is an enzyme that relies on NADPH to reduce aldehyde groups into alcohols. We extracted mesenchymal stem cells (MSCs) from human bone marrow and Wharton’s jelly to… read more here.

Keywords: expression; physiology; differentiation mscs; akr1a1 ... See more keywords

UHRF1 associated with osteogenic differentiation of MSCs contributes to osteosarcoma progression and has clinical prognostic impact in osteosarcoma.

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recommendations! Published in 2022 at "Critical reviews in eukaryotic gene expression"

DOI: 10.1615/critreveukaryotgeneexpr.2021041503

Abstract: Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) can mediate DNA methylation and histone modifications in the epigenetic regulation of gene expression, stem cell differentiation and tumorigenesis. Here, we analyzed the differentially expressed… read more here.

Keywords: differentiation; differentiation mscs; osteosarcoma progression; osteosarcoma ... See more keywords

MiR-374b promotes osteogenic differentiation of MSCs by degrading PTEN and promoting fracture healing.

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recommendations! Published in 2018 at "European review for medical and pharmacological sciences"

DOI: 10.26355/eurrev_201806_15149

Abstract: OBJECTIVE To investigate whether miR-374b can promote the differentiation of MSCs into osteoblasts by mediating PTEN, thus promoting fracture healing. MATERIALS AND METHODS Primary cultured mouse mesenchymal stem cells were obtained for following experiments. Flow… read more here.

Keywords: mir 374b; differentiation mscs; promoting fracture; mscs ... See more keywords