Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104118
Abstract: The in vivo proliferation and viability of transfused engineered T cells markedly limits the long-term effect of adoptive cell therapy on tumors. The therapeutic efficacy and proliferative potential of T cells are reported to be… read more here.
Keywords: cell; differentiation specific; specific transcription; differentiation ... See more keywords