Molecular Beacon Imaging System to Discriminate the Differentiation State of Cells from Energy Metabolic Pathways.
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DOI: 10.1021/acssensors.3c00106
Abstract: Metabolic pathways of energy production play an essential role as a function of cells. It is well recognized that the differentiation state of stem cells is highly associated with their metabolic profile. Therefore, visualization of… read more here.
Keywords: energy metabolic; energy; differentiation state; differentiation ... See more keywords
Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation
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DOI: 10.1158/0008-5472.can-24-1090
Abstract: A method merging multicolor flow cytometry with single-cell whole genome sequencing to couple cell identity with clonal lineages uncovers differentiation-state plasticity in leukemia, reconciling blocked differentiation with phenotypic plasticity in cancer. read more here.
Keywords: differentiation; plasticity; leukemia; state plasticity ... See more keywords
Abstract 1504: Opposing roles of FoxM1 and the hepatic specification genes FoxA1/A2 dictate differentiation state of liver cancer cells
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DOI: 10.1158/1538-7445.am2018-1504
Abstract: The pro-proliferation transcription factor FoxM1 is over-expressed mainly in high-grade cancers. However, the significance of its over-expression in cancers, including poorly differentiated hepatocellular carcinoma (HCC), is not known. Here we provide evidence for a causal… read more here.
Keywords: opposing roles; differentiation state; differentiation; genes foxa1 ... See more keywords
Influence of AML Differentiation State in Risk Stratification of Frontline Therapy with Hypomethylating Agents + Venetoclax in AML
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DOI: 10.1182/blood-2024-201532
Abstract: Background: Acute myeloid leukemia (AML) with monocytic differentiation can be associated with resistance to hypomethylating agents plus venetoclax (HMA+VEN). Using a multi-modal analysis in newly diagnosed patients with AML treated with HMA+VEN, we assessed the… read more here.
Keywords: differentiation; genetics; differentiation state; aml differentiation ... See more keywords