GSK126 alleviates the obesity phenotype by promoting the differentiation of thermogenic beige adipocytes in diet-induced obese mice.
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DOI: 10.1016/j.bbrc.2018.04.073
Abstract: A close relationship between epigenetic regulation and obesity has been demonstrated in several recent studies. Histone methyltransferase enhancer of Zeste homolog 2 (Ezh2), which mainly catalyzes trimethylation of histone H3K27 to form H3K27me3 was found… read more here.
Keywords: beige adipocytes; thermogenic beige; promoting differentiation; differentiation ... See more keywords