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Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01789
Abstract: Antivirulence agents targeting endospore-transmitted Clostridioides difficile infections are urgently needed. C. difficile-specific DNA adenine methyltransferase (CamA) is required for efficient sporulation and affects persistence in the colon. The active site of CamA is conserved and…
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Keywords:
dna;
clostridioides difficile;
specific dna;
difficile specific ... See more keywords
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2
Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.3c00035
Abstract: S-Adenosyl-l-methionine (SAM) analogs are adaptable tools for studying and therapeutically inhibiting SAM-dependent methyltransferases (MTases). Some MTases play significant roles in host–pathogen interactions, one of which is Clostridioides difficile-specific DNA adenine MTase (CamA). CamA is needed…
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Keywords:
dna;
clostridioides difficile;
specific dna;
difficile specific ... See more keywords