Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.10.002
Abstract: Clostridium difficile causes increasing numbers of life-threatening intestinal infections. Symptoms associated with C. difficile infection (CDI) are mediated by secreted protein toxins, whose virulence is modulated by intracellular auto-proteolysis following allosteric activation of their protease domains… read more here.
Keywords: auto; clostridium difficile; toxin auto; difficile toxin ... See more keywords
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature microbiology"
DOI: 10.1038/s41564-019-0464-z
Abstract: Clostridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic epithelium during C. difficile infection. TcdA contains a carbohydrate-binding combined repetitive oligopeptides (CROPs) domain that mediates its attachment to cell… read more here.
Keywords: clostridium difficile; tcda; low density; difficile toxin ... See more keywords
Effect of restricted dissolved oxygen on expression of Clostridium difficile toxin A subunit from E. coli
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59978-1
Abstract: The repeating unit of the C. difficile Toxin A (rARU, also known as CROPS [combined repetitive oligopeptides]) C-terminal region, was shown to elicit protective immunity against C. difficile and is under consideration as a possible… read more here.
Keywords: difficile; difficile toxin; expression; dissolved oxygen ... See more keywords
627. Differences in C. difficile Toxin A Binding in Humans: Adults vs. Infants
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.634
Abstract: Abstract Background Children less than 1 year of age are commonly colonized with toxin-producing C. difficile, but appear to be immune to the associated colitis. Animal studies suggest that young infants lack receptors for C.… read more here.
Keywords: adult; surface; toxin binding; difficile toxin ... See more keywords
Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology Research and Practice"
DOI: 10.1155/2017/8438172
Abstract: Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes… read more here.
Keywords: clostridium difficile; difficile toxin; toxin; rtx ... See more keywords
Structure and conformational dynamics of Clostridioides difficile toxin A
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201383
Abstract: This study presents a complete structural model of TcdA holotoxin and sheds new lights into the conformational dynamics of TcdA and its roles in TcdA intoxication. Clostridioides difficile toxin A and B (TcdA and TcdB)… read more here.
Keywords: difficile toxin; structure; clostridioides difficile; tcda ... See more keywords
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.978858
Abstract: Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for… read more here.
Keywords: difficile toxin; epitopes clostridioides; clostridioides difficile; neutralizing epitopes ... See more keywords
Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1110541
Abstract: Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the combined repetitive oligopeptides domain of Clostridiodes difficile toxin A (TcdA) reveal that the C-terminus of VHH A20 was located 30 Å away… read more here.
Keywords: difficile toxin; a20; design; terminus ... See more keywords
Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer?
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098155
Abstract: Clostridioides difficile (C. difficile) is responsible for a high percentage of gastrointestinal infections and its pathological activity is due to toxins A and B. C. difficile infection (CDI) is increasing worldwide due to the unstoppable… read more here.
Keywords: clostridioides difficile; difficile toxin; colorectal cancer; senescent cells ... See more keywords
The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1612.12012
Abstract: Clostridium difficile, which causes pseudomembranous colitis, releases toxin A and toxin B. These toxins are considered to be the main causative agents for the disease pathogenesis, and their expression is associated with a marked increase… read more here.
Keywords: inflammation; difficile toxin; toxin; toxin induced ... See more keywords