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   Articles with "difficult treat" as a keyword



Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer

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recommendations! Published in 2019 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2019.13968

Abstract: This cohort study evaluates the feasibility and utility of incorporating comparative gene expression information into the precision medicine framework for difficult-to-treat pediatric and young adult patients with cancer. read more here.

Keywords: young adult; pediatric young; patients cancer; difficult treat ... See more keywords

A new direction for adjunctive therapy of difficult-to-treat depression: examining the role of orexin receptor antagonists

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recommendations! Published in 2025 at "European Archives of Psychiatry and Clinical Neuroscience"

DOI: 10.1007/s00406-025-01999-w

Abstract: One of the several pressing unmet needs in the pharmacotherapy of MDD is development of drugs with novel mechanisms of action that can effectively treat depressed patients who do not respond to first- and second-line… read more here.

Keywords: difficult treat; orexin; orexin receptor; receptor antagonists ... See more keywords

Allergen-specific immunotherapy, novel drugs and biologicals: hopes from the difficult-to-treat allergic child

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recommendations! Published in 2019 at "Aerobiologia"

DOI: 10.1007/s10453-019-09573-3

Abstract: In the last decades, significant progresses have been reached in the management of atopic diseases in childhood. Several approaches have been proposed in patients affected by moderate-to-severe atopic diseases. Severe asthma and atopic dermatitis are… read more here.

Keywords: difficult treat; atopic diseases; allergen specific; specific immunotherapy ... See more keywords
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Difficult to treat asthma – The importance of thoracic imaging

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recommendations! Published in 2020 at "Respiratory Medicine Case Reports"

DOI: 10.1016/j.rmcr.2020.101127

Abstract: Asthma is a chronic disease with clinical variations throughout its course. Periods of symptom aggravation can occur with the need to escalate therapy. Nevertheless, further investigation should be considered when atypical manifestations appear or when… read more here.

Keywords: treat asthma; medicine; asthma importance; thoracic imaging ... See more keywords
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CBT for difficult-to-treat depression: self-regulation model.

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recommendations! Published in 2023 at "Behavioural and cognitive psychotherapy"

DOI: 10.1017/s1352465822000273

Abstract: BACKGROUND Cognitive behavioural therapy (CBT) is an effective treatment for depression but a significant minority of clients do not complete therapy, do not respond to it, or subsequently relapse. Non-responders, and those at risk of… read more here.

Keywords: difficult treat; cbt; depression; self regulation ... See more keywords
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Screening for the Most Common Mutations of CFTR Gene among Egyptian Children with Difficult-to-Treat Asthma.

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recommendations! Published in 2020 at "Journal of pediatric genetics"

DOI: 10.1055/s-0040-1701446

Abstract: Cystic fibrosis (CF) is panethnic autosomal recessive disease that affects the exocrine glands of pancreas, lungs, and intestine. It is often misdiagnosed in developing countries as difficult-to-treat asthma. We enrolled 150 Egyptian families with one… read more here.

Keywords: difficult treat; treat asthma; common mutations; cftr gene ... See more keywords

The continuous laryngoscopy exercise test in severe or in difficult-to-treat asthma in adults: a systematic review

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recommendations! Published in 2022 at "Journal of Asthma"

DOI: 10.1080/02770903.2022.2029481

Abstract: Abstract Objective A systematic review was performed to determine if the continuous laryngoscopy exercise test (CLE) has been used in the diagnostics of exercise dyspnea in adults with asthma, and whether inducible laryngeal obstruction (ILO)… read more here.

Keywords: difficult treat; asthma; systematic review; test ... See more keywords

Regional variation in prevalence of difficult-to-treat asthma and oral corticosteroid use for patients in Australia: heat map analysis

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recommendations! Published in 2022 at "Journal of Asthma"

DOI: 10.1080/02770903.2022.2093217

Abstract: Abstract Background In Australia, the regional prevalence of difficult-to-treat asthma is unknown. We aimed to describe regional variation in difficult-to-treat asthma prevalence and oral corticosteroid (OCS) use. Methods In this retrospective, observational, longitudinal study using… read more here.

Keywords: difficult treat; prevalence difficult; treat; treat asthma ... See more keywords

Pharmacotherapeutic approaches for treating psoriasis in difficult-to-treat areas

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recommendations! Published in 2018 at "Expert Opinion on Pharmacotherapy"

DOI: 10.1080/14656566.2018.1448788

Abstract: ABSTRACT Introduction: Despite great therapeutic advancements in psoriasis, four notable difficult-to-treat areas including the scalp, nails, intertriginous (including genitals), and palmoplantar regions, pose a challenge to both physicians and patients. Localized disease of these specific… read more here.

Keywords: pharmacotherapeutic approaches; difficult treat; approaches treating; psoriasis ... See more keywords

Jumping into the future: overcoming pharmacokinetic/pharmacodynamic hurdles to optimize the treatment of severe difficult to treat-Gram-negative infections with novel beta-lactams

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recommendations! Published in 2023 at "Expert Review of Anti-infective Therapy"

DOI: 10.1080/14787210.2023.2169131

Abstract: ABSTRACT Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR) Gram-negative infections currently represents an unmet clinical need. Areas covered This review provides a critical reappraisal of real-world evidence supporting the role of… read more here.

Keywords: dtr gram; difficult treat; novel beta; negative infections ... See more keywords

Toward precision in psoriatic arthritis: addressing the challenge of difficult-to-treat disease

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recommendations! Published in 2025 at "Expert Review of Clinical Immunology"

DOI: 10.1080/1744666x.2025.2575355

Abstract: ABSTRACT Introduction Difficult-to-treat psoriatic arthritis (D2T-PsA) is increasingly recognized as a complex clinical entity characterized by persistent disease burden despite multiple targeted therapies. Its identification is essential to improve patient outcomes and to guide the… read more here.

Keywords: disease; toward precision; psoriatic arthritis; difficult treat ... See more keywords