Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.45836
Abstract: Key Points Questions What is the incidence rate of germline alterations in CDH1, which has been reported as a susceptibility gene present in 25% to 50% of patients with hereditary diffuse gastric cancer (HDGC), and… read more here.
Keywords: germline alterations; patients hereditary; hereditary diffuse; gastric cancer ... See more keywords
The benefits of a model of interval comprehensive assessments (MICA) in hereditary cancer Syndromes: Hereditary diffuse gastric cancer (HDGC) as an example.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.03.005
Abstract: A high percentage of individuals at risk for hereditary cancer syndromes are unaware of their risk. This is especially detrimental in syndromes such as hereditary diffuse gastric cancer due to a CDH1 germline mutation, for… read more here.
Keywords: diffuse gastric; hereditary diffuse; cancer; interval comprehensive ... See more keywords
Hereditary Diffuse Gastric Cancer (HDGC). An overview.
Sign Up to like & getrecommendations! Published in 2021 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2021.101820
Abstract: It is estimated that up to 10% of gastric carcinomas show familial aggregation. In contrast, around 1-3 % (approximately 33,000 yearly) are genuinely hereditary. Hereditary diffuse gastric cancer (HDGC) is a rare malignancy characterized by… read more here.
Keywords: hdgc; hereditary diffuse; gastric cancer; diffuse gastric ... See more keywords
Early genetic counseling and detection of CDH1 mutation in asymptomatic carriers improves survival in hereditary diffuse gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Surgery"
DOI: 10.1016/j.surg.2018.05.059
Abstract: Background: Hereditary diffuse gastric cancer is associated with E‐cadherin (CDH1) germline mutations. The implications of CDH1 mutations detected with multigene panels in those without family history of HDGC are uncertain. Methods: A registry of patients… read more here.
Keywords: cancer; diffuse gastric; cdh1 mutation; gastric cancer ... See more keywords
Targeting GPX2 to disrupt lipid homeostasis and enhance cisplatin sensitivity in diffuse gastric cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02771-8
Abstract: Diffuse gastric cancer (DGC) is characterized by high malignancy and metastasis rate, and poorly understood etiology, culminating in dismal patient outcomes. Here, through comprehensive analysis, we identified that glutathione peroxidase 2 (GPX2) plays a pivotal… read more here.
Keywords: diffuse gastric; cancer; gastric cancer; lipid homeostasis ... See more keywords
Outcomes of Endoscopic Surveillance in Individuals With Genetic Predisposition to Hereditary Diffuse Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.03.047
Abstract: BACKGROUND & AIMS Pathogenic germline variants in CDH1 are associated with risk for diffuse gastric cancer (DGC) and lobular breast cancer. The reported high incidence of DGC and limited sensitivity of endoscopy in detection have… read more here.
Keywords: variants cdh1; gastric cancer; family; diffuse gastric ... See more keywords
Hereditary Diffuse Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.01.038
Abstract: Hereditary Diffuse Gastric Cancer (HDGC) is a dominantly-inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). HDGC is caused by germline mutations in two genes involved… read more here.
Keywords: hereditary diffuse; gastric cancer; diffuse gastric; cancer ... See more keywords
Clinical decision tree for optimizing endoscopic assessment of signet ring cell carcinoma in hereditary diffuse gastric cancer surveillance
Sign Up to like & getrecommendations! Published in 2025 at "Endoscopy"
DOI: 10.1055/a-2634-7895
Abstract: Abstract Background Prophylactic total gastrectomy is the definitive treatment for hereditary diffuse gastric cancer syndrome (HDGC). Endoscopic surveillance informs the requirement for and optimal timing of surgery. However, endoscopic recognition of early signet ring cell… read more here.
Keywords: diffuse gastric; cancer; surveillance; gastric cancer ... See more keywords
Hereditary Diffuse Gastric Cancer: Approaches to Screening, Surveillance, and Treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of medicine"
DOI: 10.1146/annurev-med-051019-103216
Abstract: Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome associated with a significant lifetime risk of diffuse gastric cancer (DGC), a malignancy characterized by late clinical presentation and poor prognosis, as well as lobular breast… read more here.
Keywords: medicine; hereditary diffuse; gastric cancer; diffuse gastric ... See more keywords
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0811
Abstract: Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the GTPase RHOA. The function of… read more here.
Keywords: gastric cancer; function; kinase; diffuse gastric ... See more keywords
Fraction of diffuse gastric cancer attributable to dietary risk factors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e16042
Abstract: e16042Background: Gastric cancer is a major health problem worldwide, especially in Brazil, where incidence rate is moderate-high. Although intestinal type of gastric cancer is clearly associated with environmental risk factors, the contribution of these modifiable… read more here.
Keywords: dietary risk; gastric cancer; risk factors; diffuse gastric ... See more keywords