Prognostic impact of distinct genetic entities in pediatric diffuse glioma WHO‐grade II—Report from the German/Swiss SIOP‐LGG 2004 cohort
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DOI: 10.1002/ijc.32995
Abstract: Reports on pediatric low‐grade diffuse glioma WHO‐grade II (DG2) suggest an impaired survival rate, but lack conclusive results for genetically defined DG2‐entities. We analyzed the natural history, treatment and prognosis of DG2 and investigated which… read more here.
Keywords: diffuse; diffuse glioma; treatment; german swiss ... See more keywords
Cognitive impairments are independently associated with shorter survival in diffuse glioma patients
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DOI: 10.1007/s00415-020-10303-w
Abstract: Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits are of important prognostic value for survival in diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological… read more here.
Keywords: diffuse; diffuse glioma; survival diffuse; cognitive functioning ... See more keywords
Perioperative fatigue in patients with diffuse glioma
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DOI: 10.1007/s11060-020-03403-0
Abstract: Purpose Few studies have assessed fatigue in relation to glioma surgery. The purpose of this study was to explore the prevalence of pre- and postoperative high fatigue, perioperative changes, and factors associated with pre- and… read more here.
Keywords: surgery; diffuse glioma; fatigue; high fatigue ... See more keywords
Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional pharmacogenetic study
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DOI: 10.1007/s11060-022-03944-6
Abstract: Nearly 10% of patients with adult diffuse glioma develop clinically significant myelotoxicity while on temozolomide (TMZ) leading to treatment interruptions. This study aimed to assess single nucleotide polymorphisms (SNPs) in the O6-methylguanine-DNA methyltransferase (MGMT) gene… read more here.
Keywords: diffuse glioma; patients adult; mgmt gene; induced myelotoxicity ... See more keywords
Evidence-based recommendations on categories for extent of resection in diffuse glioma.
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DOI: 10.1016/j.ejca.2021.03.002
Abstract: Surgical resection represents the standard of care in diffuse glioma, and more extensive tumour resection appears to be associated with favourable outcome. Up to now, terminology to describe extent of resection has been inconsistently applied… read more here.
Keywords: categories extent; extent resection; diffuse glioma; evidence based ... See more keywords
Management of diffuse glioma.
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DOI: 10.1016/j.lpm.2018.04.014
Abstract: Diffuse gliomas constitute a diverse group of malignant brain tumors with varying aggressive course and heterogeneous survival. Although the mainstay of treatment of these distinct tumors is still based on the combination of surgery and… read more here.
Keywords: management diffuse; diffuse; treatment; diffuse glioma ... See more keywords
Hemodynamic investigation of peritumoral impaired blood oxygenation-level dependent cerebrovascular reactivity in patients with diffuse glioma.
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DOI: 10.1016/j.mri.2020.03.012
Abstract: Abstract Introduction The presence of peritumorally impaired blood oxygenation-level dependent cerebrovascular reactivity (BOLD-CVR) has been unequivocally demonstrated in patients with diffuse glioma, and may have value to better identify tumor infiltration zone. Since BOLD-CVR does… read more here.
Keywords: oxygenation level; diffuse glioma; blood; impaired blood ... See more keywords
NIMG-32. THE PREDICTIVE CAPACITY OF PRE-OPERATIVE IMAGING ANALYSIS IN DIFFUSE GLIOMA: A COMPARISON OF CONNECTOMICS, RADIOMICS, AND CLINICAL PREDICTIVE MODELS
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DOI: 10.1093/neuonc/noaa215.645
Abstract: Radiomics and connectome analysis are distinct and non-invasive methods of deriving biologic information from MRI. Radiomics analyzes features intrinsic to the tumor, and connectomics incorporates data regarding the tumor and surrounding neural circuitry. In this… read more here.
Keywords: radiomics clinical; diffuse glioma; connectomics; analysis ... See more keywords
NCOG-08. COGNITIVE DEFICITS AS A PREDICTOR OF THE COURSE OF TREATMENT IN DIFFUSE GLIOMA
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DOI: 10.1093/neuonc/noz175.669
Abstract: Over half of patients with a diffuse glioma suffer from cognitive deficits in one or more domains. Cognitive functioning, especially for the domains executive functioning (EF) and memory, is an independent prognostic factor for overall… read more here.
Keywords: risk complications; cognitive deficits; diffuse glioma; patients cognitive ... See more keywords
Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.
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DOI: 10.1093/nop/npac017
Abstract: Knowledge about inherited and acquired genetics of adult diffuse glioma has expanded significantly over the past decade. Genomewide association studies (GWAS) stratified by histologic subtype identified six germline variants that were associated specifically with glioblastoma… read more here.
Keywords: adult diffuse; diffuse glioma; polygenic risk; risk ... See more keywords
Molecular pathology and clinical implications of diffuse glioma
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DOI: 10.1097/cm9.0000000000002446
Abstract: Abstract The prognosis for diffusely infiltrating gliomas at World Health Organization (WHO) grade 2–4 remains dismal due to their heterogeneity. The rapid development of genome-wide molecular-profiling-associated studies has greatly promoted the accuracy of glioma classification.… read more here.
Keywords: clinical implications; diffuse glioma; implications diffuse; molecular pathology ... See more keywords