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   Articles with "diffuse intrinsic" as a keyword



Signal Transduction in Diffuse Intrinsic Pontine Glioma

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recommendations! Published in 2019 at "PROTEOMICS"

DOI: 10.1002/pmic.201800479

Abstract: Diffuse intrinsic pontine glioma (DIPG) is an untreatable, heterogeneous high‐grade glioma (HGG) of the brainstem. This highly aggressive cancer affects mostly young children and is uniformly fatal. Genomic studies show that DIPG is driven by… read more here.

Keywords: diffuse intrinsic; intrinsic pontine; glioma; pontine glioma ... See more keywords

Reirradiation for diffuse intrinsic pontine glioma: prognostic radiomic factors at progression

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recommendations! Published in 2024 at "Strahlentherapie Und Onkologie"

DOI: 10.1007/s00066-024-02241-7

Abstract: Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor. Radiation therapy (RT) is the standard treatment, with reirradiation considered in case of progression. However, the prognostic factors for reirradiation are not well understood.… read more here.

Keywords: pontine glioma; progression; reirradiation; diffuse intrinsic ... See more keywords

H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo

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recommendations! Published in 2019 at "Acta Neuropathologica"

DOI: 10.1007/s00401-019-01975-4

Abstract: Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the… read more here.

Keywords: diffuse intrinsic; intrinsic pontine; differentiation; k27m ... See more keywords
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Retrospective study of diffuse intrinsic pontine glioma in the Belgian population: a 25 year experience

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recommendations! Published in 2021 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-021-03766-y

Abstract: Diffuse intrinsic pontine glioma is a rare disease with a high mortality. Our primary aim was to determine the incidence of this disease in Belgium. Secondly, we wanted to compare the treatment approach of Belgian… read more here.

Keywords: diffuse intrinsic; intrinsic pontine; oncology; pontine glioma ... See more keywords

Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials

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recommendations! Published in 2019 at "Current Treatment Options in Neurology"

DOI: 10.1007/s11940-019-0577-y

Abstract: This review of diffuse intrinsic pontine glioma (DIPG) provides clinical background, a systematic approach to diagnosis and initial care, and synthesizes historical, modern, and future directions for treatment. We present evidence supporting neurosurgical biopsy, early… read more here.

Keywords: diffuse intrinsic; glioma; intrinsic pontine; clinical trials ... See more keywords

Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma

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recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.04.043

Abstract: Background Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain cancer without cure. Seeking therapeutic strategies is still a major challenge in DIPG research. Previous study has shown that dysregulation of G1/S… read more here.

Keywords: diffuse intrinsic; treatment; intrinsic pontine; dipg ... See more keywords

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

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recommendations! Published in 2019 at "European journal of cancer"

DOI: 10.1016/j.ejca.2019.03.019

Abstract: PURPOSE Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to… read more here.

Keywords: diffuse intrinsic; medicine; study; brainstem biopsy ... See more keywords

Safety and efficacy of Endoscopic Third Ventriculostomy in Diffuse Intrinsic Pontine Glioma related hydrocephalus: a Systematic Review.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2018.12.096

Abstract: OBJECT Diffuse Intrinsic Pontine Gliomas (DIPG) related hydrocephalus occurs as the result of tumor growth and Aqueduct obstruction. There is no consensus about the best surgical option, thus a review has been performed to clarify… read more here.

Keywords: diffuse intrinsic; endoscopic third; intrinsic pontine; review ... See more keywords
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Rare Diffuse Intrinsic Pontine Glioma Metastasis Throughout the Brain and Spine.

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recommendations! Published in 2020 at "World neurosurgery"

DOI: 10.1016/j.wneu.2020.05.205

Abstract: Diffuse intrinsic pontine glioma (DIPG) with H3 K27M mutation is a rare brain tumor that primarily affects children. It is extremely lethal, and our understanding of the natural course of this disease, and how it… read more here.

Keywords: diffuse intrinsic; throughout brain; brain spine; intrinsic pontine ... See more keywords

Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma.

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recommendations! Published in 2020 at "ACS applied nano materials"

DOI: 10.1021/acsanm.0c02297

Abstract: Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used… read more here.

Keywords: diffuse intrinsic; focused ultrasound; 64cu cuncs; delivery ... See more keywords

Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial

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recommendations! Published in 2025 at "Nature Medicine"

DOI: 10.1038/s41591-024-03451-3

Abstract: Diffuse intrinsic pontine glioma (DIPG) is a fatal central nervous system (CNS) tumor that confers a median survival of 11 months. As B7-H3 is expressed on pediatric CNS tumors, we conducted BrainChild-03, a single-center, dose-escalation phase… read more here.

Keywords: pontine glioma; trial; car; car cells ... See more keywords