A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24189
Abstract: Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are… read more here.
Keywords: diffuse midline; mouse; origin dependent; midline glioma ... See more keywords
Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma
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DOI: 10.1007/s00062-021-01120-3
Abstract: Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1… read more here.
Keywords: molecular subgroups; diffuse midline; k27m; midline glioma ... See more keywords
Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02142-w
Abstract: Diffuse midline gliomas (DMG) H3 K27M-mutant was introduced in the 2016 WHO Classification of Tumors of the Central Nervous System, unifying diffuse intrinsic pontine gliomas (DIPG) and gliomas from the thalamus and spinal cord harboring… read more here.
Keywords: diffuse; midline gliomas; gliomas; diffuse midline ... See more keywords
Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04489-0
Abstract: H3K27M mutant diffuse midline gliomas (DMGs) are considered grade IV irrespective of histological features and have dismal prognosis. We evaluated clinico-pathologic, radiological, and molecular characteristics of DMGs across all ages. One twenty-six DMGs were identified… read more here.
Keywords: midline gliomas; h3k27m; diffuse midline; h3k27m mutation ... See more keywords
National trends in the treatment of adult diffuse midline gliomas: a rare clinical scenario
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DOI: 10.1007/s11060-024-04663-w
Abstract: Diffuse midline gliomas (DMG) include all midline gliomas with a point mutation to the histone H3 gene resulting in the substitution of a lysine with a methionine (K27M). These tumors are classified as World Health… read more here.
Keywords: diffuse midline; adult; midline gliomas;
Diffuse midline glioma metastasis to the peritoneal cavity via ventriculo-peritoneal shunt: Case report and review of literature
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.06.043
Abstract: Extraneural dissemination of primary intracranial tumours to the peritoneal cavity via ventriculoperitoneal shunts is rare, with medulloblastoma and germ-cell tumours most common and gliomas seldom implicated. This report is the first described case of a… read more here.
Keywords: peritoneal cavity; cavity via; glioma; midline glioma ... See more keywords
An atypical presentation of diffuse midline pontine glioma in a middle age patient: Case report
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.08.096
Abstract: INTRODUCTION Diffuse midline glioma is a newly WHO defined entity (grade IV) (Louis et al., 2016) which includes diffuse intrinsic pontine glioma (DIPG) reported in pediatric population and, occasionally, in young adults. Here, we present… read more here.
Keywords: pontine glioma; diffuse midline; glioma; case ... See more keywords
Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma
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DOI: 10.1038/s41467-024-52973-4
Abstract: H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-like cells. Here, we establish in vitro models that recapitulate… read more here.
Keywords: like cells; therapeutic targeting; targeting differentiation; opc like ... See more keywords
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
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DOI: 10.1038/s41586-024-08171-9
Abstract: H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models1. Arm A of Phase I trial no. NCT04196413 (ref. 2) administered… read more here.
Keywords: gd2 cart; gd2; diffuse midline; midline gliomas ... See more keywords
Transcriptomic and proteomic spatial profiling of pediatric and adult diffuse midline glioma H3 K27-Altered
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DOI: 10.1038/s41598-024-73199-w
Abstract: Diffuse midline glioma, H3 K27-altered (DMG) are highly aggressive malignancies of the central nervous system (CNS) that primarily affect the pediatric population. Large scale spatial transcriptomic studies have implicated that tumor microenvironmental landscape plays an… read more here.
Keywords: k27; k27 altered; midline glioma; glioma k27 ... See more keywords
Mosaic Pattern of H3 K27M-Mutant Protein Expression in a Diffuse Midline Glioma—A Diagnostic Dilemma for the Pathologist
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosciences in Rural Practice"
DOI: 10.1055/s-0041-1728231
Abstract: Diffuse midline glioma, H3 K27M-mutant, is a World Health Organization (WHO) grade IV glioma arising in pons, thalamus, and spinal cord. They show mutations resulting in replacement of lysine at position 27 by methionine (K27M)… read more here.
Keywords: glioma; diffuse midline; k27m mutant; k27m ... See more keywords