Regio- and Stereoselective Addition to gem-Difluorinated Ene-Ynamides: Access to Stereodefined Fluorinated Dienes.
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DOI: 10.1021/acs.orglett.2c01593
Abstract: The first synthesis of gem-difluorinated ene-ynamides is presented via deprotonation of trifluoromethylated N-allenamides and δ extrusion of fluorine. These highly reactive building blocks, owing to their dual functional groups, offer a unique entry to difluorinated… read more here.
Keywords: addition; gem difluorinated; ene ynamides; difluorinated ene ... See more keywords