Synthesis of 6,6‐ and 7,7‐Difluoro‐1‐acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200081
Abstract: LolO, a 2‐oxoglutarate‐dependent nonheme Fe oxygenase, catalyzes both the hydroxylation of 1‐exo‐acetamidopyrrolizidine (AcAP), a pathway intermediate in the biosynthesis of the loline alkaloids, and the cycloetherification of the resulting alcohol. We have prepared fluorinated AcAP… read more here.
Keywords: difluoro; nonheme oxygenase; acap; synthesis difluoro ... See more keywords
Synthesis of 2-fluoro-substituted and 2,6-modified purine 2',3'-dideoxy-2',3'-difluoro-d-arabinofuranosyl nucleosides from d-xylose.
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.02.027
Abstract: A series of novel purine-modified 2',3'-dideoxy-2',3'-difluro-D-arabinonucleosides, including fluorinated analogs of fludarabine and nelarabine, have been prepared via anion glycosylation reactions of salts of 2-fluoropurine derivatives with the glycosyl bromide. A short and efficient synthetic route… read more here.
Keywords: difluoro; synthesis fluoro; difluoro arabinofuranosyl; purine ... See more keywords
Palladium/Amino Acid Co-catalyzed Atroposelective C-H Olefination to Access Tetra-Ortho-Substituted Atropisomers Featuring 2,2'-Difluoro-1-biaryl Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02303
Abstract: Despite the great advancement in atroposelective synthesis in the past decades, the enantioselective synthesis of 2,2'-difluoro-1-biaryls is unprecedented. Herein, a palladium and chiral amino acid catalyzed atroposelective C-H olefination to construct the axially chiral 2,2'-difluoro-1-biaryls… read more here.
Keywords: difluoro; atroposelective olefination; amino acid; catalyzed atroposelective ... See more keywords
Electrochemical Difunctionalization of gem-Difluoroalkenes: A Metal-Free Synthesis of α-Difluoro(alkoxyl/azolated) Methylated Ethers.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01130
Abstract: A scalable electrochemical difunctionalization of gem-difluoroalkenes to structurally versatile difluoro motifs was achieved. This methodology features reagent-free conditions, good functional group tolerance, and a relatively broad substrate scope. Meanwhile, the electrolysis protocol is easy to… read more here.
Keywords: difunctionalization gem; gem difluoroalkenes; difluoro; electrochemical difunctionalization ... See more keywords
Synthesis of 2,2-difluoro-3H-benzothiophen-3-ol via a difluorocarbene insertion reaction, investigating the scope for further derivatization
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1614629
Abstract: Abstract A simple, and efficient synthesis of 2,2-difluoro-3H-benzothiophen-3-ol using readily available sodium chlorodifluoroacetate (SCDA) is reported. We also explore new chemistry of these difluoro compounds. The salient feature of this approach includes operational simplicity and… read more here.
Keywords: difluoro benzothiophen; benzothiophen via; synthesis difluoro; difluoro ... See more keywords