Synthesis of Difluoroalkylated Benzofuran, Benzothiophene, and Indole Derivatives via Palladium-Catalyzed Cascade Difluoroalkylation and Arylation of 1,6-Enynes.
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DOI: 10.1021/acs.orglett.9b04681
Abstract: A novel and efficient method for the synthesis of difluoroalkylated benzofuran, benzothiophene, and indole derivatives via palladium-catalyzed aryldifluoroalkylation of 1,6-enynes with ethyl difluoroiodoacetate and arylboronic acids has been established. High reaction efficiency, mild conditions, broad… read more here.
Keywords: benzofuran benzothiophene; difluoroalkylated benzofuran; synthesis difluoroalkylated; indole derivatives ... See more keywords