DMSO-Promoted Difluoroalkylation of Organophosphonium Salts with Difluoroenol Silyl Ethers.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02088
Abstract: An efficient method for the synthesis of β,β-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic… read more here.
Keywords: salts difluoroenol; difluoroenol silyl; silyl ethers; organophosphonium salts ... See more keywords
Photocatalytic site-selective C-H difluoroalkylation of aromatic aldehydes.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc09586a
Abstract: The direct photocatalyzed para-selective CAr-H difluoroalkylation of aromatic aldehyde derivatives has been accomplished using a newly explored catalytic system. In addition, when using para-substituted benzaldehydes as substrates, ortho-selective CAr-H difluoroalkylation was also accomplished. It is… read more here.
Keywords: photocatalytic site; site selective; difluoroalkylation aromatic; difluoroalkylation ... See more keywords
Copper-Catalyzed Difluoroalkylation Reaction
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238461
Abstract: This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The RCF2 radical is generally proposed in the mechanism of these reactions. At present, various types of copper-catalyzed difluoroalkylation reactions have been realized. According to their… read more here.
Keywords: catalyzed difluoroalkylation; difluoroalkylation; copper catalyzed; difluoroalkylation reactions ... See more keywords