Ruthenium-Catalyzed Ligand-Enabled Regiodivergent Difluoroallylation of Aryl C-H Bonds.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00873
Abstract: The gem-difluoroallyl group is a sought-after structural motif commonly found in pharmaceutical compounds. Despite its appeal, achieving a controlled synthesis of both α,α- and γ,γ-difluoroallylated compounds has proven to be a challenging task. This study… read more here.
Keywords: catalyzed ligand; ligand enabled; regiodivergent difluoroallylation; ruthenium catalyzed ... See more keywords
Direct C-H difluoroallylation of α,β-unsaturated amides and aryl amides by rhodium catalysis.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d4cc03804e
Abstract: Herein, we report the first example of Rh-catalyzed C(sp2)-H difluoroallylation of α,β-unsaturated amides with 3-bromo-3,3-difluoropropene under mild conditions. The features of this protocol for difluoroallylation are unprecedented vinylic substrates, ethanol as a green solvent, good… read more here.
Keywords: unsaturated amides; difluoroallylation; difluoroallylation unsaturated; aryl amides ... See more keywords