Study on the mild, rapid and selective difluorocarbene-mediated triclassification of iododifluoroacetophenone with secondary amines and tree model for product classification
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131762
Abstract: Abstract Difluorocarbene is a very active and widely used intermediate in organic synthesis. In this work, a room temperature difluorocarbene-mediated triclassification reaction of iododifluoroacetophenone (2) and secondary amines with mild condition, short reaction time (only… read more here.
Keywords: tree model; difluorocarbene; difluorocarbene mediated; secondary amines ... See more keywords
A Journey of the Development of Privileged Difluorocarbene Reagents TMSCF2X (X = Br, F, Cl) for Organic Synthesis.
Sign Up to like & getrecommendations! Published in 2024 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.3c00719
Abstract: ConspectusAs fluorine has played an increasingly important role in modulating the physical, chemical, and biological properties of organic molecules, the selective introduction of fluorine atom(s) or fluorinated moieties into target molecules has become a powerful… read more here.
Keywords: chemistry; difluorocarbene reagents; difluorocarbene involved; organic synthesis ... See more keywords
Pd-Catalyzed Assembly of Fluoren-9-ones by Merging of C-H Activation and Difluorocarbene Transfer.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00467
Abstract: We disclose a novel Pd-catalyzed assembly of fluoren-9-ones by merging of C-H activation and difluorocarbene transfer. ClCF2COONa served as a difluorocarbene precursor to be harnessed as a carbonyl source in this transformation. The current protocol… read more here.
Keywords: difluorocarbene; fluoren ones; catalyzed assembly; ones merging ... See more keywords
Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02816
Abstract: We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of a difluorocarbene, two different types of fluorine motifs are incorporated into the… read more here.
Keywords: double capture; difluoroethyl fluoroindoles; difluorocarbene; capture difluorocarbene ... See more keywords
Multi-component reactions via copper(I) difluorocarbene as carbonyl source for constructing α—aminoamide derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61947-z
Abstract: Difluorocarbene, an important reactive intermediate in organic synthesis, exhibits intriguing properties and synthetic versatility. However, great challenges in modulating reaction pathways limit its widespread application in synthetic chemistry. While metal-catalyzed difluorocarbene transfer offers a promising… read more here.
Keywords: via copper; carbonyl source; aminoamide derivatives; copper ... See more keywords
Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemistry"
DOI: 10.1038/s41557-019-0331-9
Abstract: Difluorocarbene has important applications in pharmaceuticals, agrochemicals and materials, but all these applications proceed using just a few types of reaction by taking advantage of its intrinsic electrophilicity. Here, we report a palladium-catalysed strategy that… read more here.
Keywords: difluorocarbene; catalytic difluorocarbene; difluorocarbene transfer; controllable catalytic ... See more keywords
Regioselective Syntheses of Fluorinated Cyclopentanone Derivatives: Ring Construction Strategy Using Transition-Metal–Difluorocarbene Complexes and Free Difluorocarbene
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1591728
Abstract: The syntheses of fluorinated cyclopentanone derivatives, which have pharmaceutical and agrochemical importance are reported. The catalytic reaction of copper(I) and nickel(II) difluorocarbenes with silyl dienol ethers afforded 4,4-difluoro- and 5,5-difluorocyclopent-1-en-1-yl silyl ethers, respectively. The fluorine-directed… read more here.
Keywords: cyclopentanone derivatives; free difluorocarbene; syntheses fluorinated; difluorocarbene ... See more keywords