Copper-Catalyzed Hydroamination of gem-Difluoroalkenes Access to Diversified α-Difluoromethyl Amines.
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DOI: 10.1021/acs.orglett.2c04278
Abstract: The difluoromethyl group (CF2H) is of great importance in medicinal chemistry. We report herein an efficient method for the synthesis of diversified α-difluoromethyl amines through copper-catalyzed hydroamination of gem-difluoroalkenes, where the C-N bond formed via… read more here.
Keywords: gem; gem difluoroalkenes; catalyzed hydroamination; difluoromethyl amines ... See more keywords