Electrochemical Difluoromethylation of Electron-Deficient Alkenes.
Sign Up to like & getrecommendations! Published in 2019 at "ChemSusChem"
DOI: 10.1002/cssc.201803058
Abstract: Electrochemical 1,2-hydroxydifluoromethylation and C-H difluoromethylation of acrylamides were developed by using CF2 HSO2 NHNHBoc as the source of the CF2 H group. These electricity-powered oxidative alkene functionalization reactions do not need transition-metal catalysts or chemical… read more here.
Keywords: electrochemical difluoromethylation; deficient alkenes; electron deficient; difluoromethylation ... See more keywords
Copper-catalyzed allylic difluoromethylation of allyl carbonates with (difluoromethyl)zinc reagent
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.07.018
Abstract: Abstract The catalytic allylic difluoromethylation of allyl carbonates with (difluoromethyl)zinc reagent, which can be readily prepared via iodine-zinc exchange reaction of difluoroiodomethane with diethylzinc, was achieved by employing copper salt as a catalyst. The difluoromethylation… read more here.
Keywords: difluoromethylation allyl; difluoromethylation; allylic difluoromethylation; difluoromethyl zinc ... See more keywords
Divergent Regioselective Csp2-H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01262
Abstract: Herein, the first catalytic protocol for nickel-catalyzed ortho or para position difluoromethylation of various aromatic amines has been developed with the assistance of a bidentate phosphine ligand, offering an invaluable synthesis means to construct extensive… read more here.
Keywords: divergent regioselective; difluoromethylation; aromatic amines; difluoromethylation aromatic ... See more keywords
Difluoromethylsulfonyl Imidazolium Salt for Difluoromethylation of Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03073
Abstract: Herein, we describe the design and synthesis of a difluoromethylsulfonyl imidazolium salt, which can act as a radical difluoromethylation reagent to achieve the challenging amino- and oxy-difluoromethylation of alkenes. Notably, the three steps for the… read more here.
Keywords: difluoromethylation alkenes; difluoromethylsulfonyl imidazolium; difluoromethylation; imidazolium salt ... See more keywords
Radical Difluoromethylation of Thiols with (Difluoromethyl)triphenylphosphonium Bromide.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02109
Abstract: A method for facile difluoromethylation of various thiols using (difluoromethyl)triphenylphosphonium bromide under mild reaction conditions is presented. The transformation proceeds in the absence of any transition metal using a bench-stable and readily accessible phosphonium salt.… read more here.
Keywords: thiols difluoromethyl; difluoromethylation thiols; radical difluoromethylation; difluoromethyl triphenylphosphonium ... See more keywords
Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of β-Ketoesters and Malonates.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03067
Abstract: Air- and light-stable electrophilic difluoromethylating reagents, S-(difluoromethyl)- S-phenyl- S-(2,4,6-trialkoxyphenyl) sulfonium salts were successfully developed, and the introduction of intramolecular hydrogen bonds plays a crucial role for the stabilities and reactivities of these reagents. C-selective difluoromethylation… read more here.
Keywords: light stable; sulfonium salts; difluoromethylation; air light ... See more keywords
Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00088e
Abstract: A simple and effective method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as the bifunctional reagent was developed. The combination of cupric catalyst and alkaline additive results in… read more here.
Keywords: difluoromethylation; bromination difluoromethylation; bromination; copper catalyzed ... See more keywords
Late-Stage Difluoromethylation of Aliphatic Carboxylic Acids with Copper Catalysis
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DOI: 10.1055/s-0039-1690798
Abstract: Difluoromethyl groups are of great importance to synthetic and pharmaceutical chemistry because of their unique properties that regulate molecular bioactivity. In this article, approaches towards difluoromethylation are discussed and the development of the first aliphatic… read more here.
Keywords: late stage; aliphatic carboxylic; carboxylic acids; difluoromethylation aliphatic ... See more keywords
Radical C–H 18F-Difluoromethylation of Heteroarenes with [18F]Difluoromethyl Heteroaryl-Sulfones by Visible Light Photoredox Catalysis
Sign Up to like & getrecommendations! Published in 2020 at "Catalysts"
DOI: 10.3390/catal10030275
Abstract: The 18F-labeling of CF2H groups has been recently studied in radiopharmaceutical chemistry owing to the favorable nuclear and physical characteristics of the radioisotope 18F for positron emission tomography (PET). Following up on the reported efficiency… read more here.
Keywords: 18f difluoromethylation; 18f difluoromethyl; 18f 18f; difluoromethyl heteroaryl ... See more keywords
Facile Entry to Pharmaceutically Important 3-Difluoromethyl-Quinoxalin-2-Ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-Ones
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15121552
Abstract: CF2H moiety has a significant potential utility in drug design and discovery, and the incorporation of CF2H into biologically active molecules represents an important and efficient strategy for seeking lead compounds and drug candidates. On… read more here.
Keywords: difluoromethylation; facile entry; difluoromethyl quinoxalin; quinoxalin ones ... See more keywords