Divergent Regioselective Csp2-H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis.
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DOI: 10.1021/acs.orglett.2c01262
Abstract: Herein, the first catalytic protocol for nickel-catalyzed ortho or para position difluoromethylation of various aromatic amines has been developed with the assistance of a bidentate phosphine ligand, offering an invaluable synthesis means to construct extensive… read more here.
Keywords: divergent regioselective; difluoromethylation; aromatic amines; difluoromethylation aromatic ... See more keywords