Selective cleaving the N P bond of difluoromethylene phosphabetaines for effective synthesis of β-ketoamides
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DOI: 10.1016/j.tetlet.2019.06.036
Abstract: Abstract An unprecedent transition-metal-free protocol for the synthesis of β-ketoamides from β-ketoesters is described. This method involves selective cleaving N P bond of an unusual aminating reagent, [tris(dimethylamino)phosphonio]difluoroacetate (ADFA), which is well known as the… read more here.
Keywords: cleaving bond; synthesis ketoamides; selective cleaving; difluoromethylene ... See more keywords