Relay Photocatalytic Reaction of N-Aryl Amino Acids and 2-Bromo-3,3,3-trifluoropropene: Synthesis of 4-(Difluoromethylidene)-tetrahydroquinolines.
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DOI: 10.1021/acs.orglett.2c01117
Abstract: The bulk industrial chemical 2-bromo-3,3,3-trifluoropropene (BTP) was first employed as a coupling partner in photocatalytic defluorinative reactions with N-aryl amino acids. Photoredox activation of the C(sp2)-Br bond of the resultant 2-bromo-1,1-difluoroalkenes generates gem-difluoro vinyl radicals… read more here.
Keywords: amino acids; difluoromethylidene tetrahydroquinolines; bromo trifluoropropene; aryl amino ... See more keywords