Mechanistic Insights into Ni-Catalyzed Difunctionalization of Alkenes Using Organoboronic Acids and Organic Halides: Understanding Remarkable Substrate-Dependent Regioselectivity
Sign Up to like & getrecommendations! Published in 2020 at "Organometallics"
DOI: 10.1021/acs.organomet.0c00043
Abstract: Transition metal catalyzed difunctionalization reactions of alkenes using simple chemical feedstocks are powerful strategies for the synthesis of valuable compounds and materials. Density functiona... read more here.
Keywords: insights catalyzed; catalyzed difunctionalization; alkenes using; mechanistic insights ... See more keywords
Photocatalytic Regioselective Difunctionalization of Alkenes with Diazo Compounds and tert-Butyl Nitrite: Access to γ-Oximino Esters.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02749
Abstract: A visible-light photocatalytic regioselective difunctionalization of alkenes with diazo compounds and tert-butyl nitrite has been developed. The protocol provides an efficient approach to γ-oximino esters under mild conditions. Significantly, this transformation not only shows the… read more here.
Keywords: difunctionalization alkenes; butyl nitrite; diazo compounds; photocatalytic regioselective ... See more keywords
A Photosensitizer for N-O Bond Activation: 2,7-Br-4CzIPN-Catalyzed Difunctionalization of Alkenes with Oxime Esters.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01073
Abstract: We developed 2,4,5,6-tetrakis(2,7-dibromo-9H-carbazol-9-yl)isophthalonitrile (2,7-Br-4CzIPN) as a new photosensitizer for the energy-transfer-driven N-O bond dissociation of oxime esters. In the presence of 2,7-Br-4CzIPN, difunctionalization of alkenes with oxime esters, including oxyimination, aminocarboxylation, and amidylimination, could afford… read more here.
Keywords: difunctionalization alkenes; photosensitizer bond; alkenes oxime; oxime esters ... See more keywords
Photosensitized 1,2-Difunctionalization of Alkenes to Access β-Amino Sulfonamides.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c00432
Abstract: A metal-free photosensitized 1,2-imino-sulfamoylation of olefins by employing a tailor-made sulfamoyl carbamate as the difunctionalization reagent has been established. This protocol exhibits versatility across a broad substrate scope, including aryl and aliphatic alkenes, leading to… read more here.
Keywords: access amino; difunctionalization alkenes; amino; photosensitized difunctionalization ... See more keywords
1,3-Difunctionalization of Alkenes by Cobaloxime Photocatalysis.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02027
Abstract: Represented herein is the first 1,3-difunctionalization of alkenes via photocatalysis. A single cobaloxime is used to carry out two catalytic cycles in which cobaloxime is used not only as a photocatalyst to initiate the reaction… read more here.
Keywords: alkenes cobaloxime; cobaloxime photocatalysis; difunctionalization alkenes; photocatalysis ... See more keywords
Heterogeneous g-C3N4/NaI Dual Catalytic Difunctionalization of Alkenes with Heteroarenes and Methyl Carbazate under Visible Light.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c01200
Abstract: Herein, a photoinduced heterogeneous catalytic system merging g-C3N4 and NaI has been established for the difunctionalization of alkenes in conjunction with heteroarenes and methyl carbazate. This approach is notable for its broad substrate tolerance, encompassing… read more here.
Keywords: alkenes heteroarenes; methyl carbazate; c3n4 nai; heteroarenes methyl ... See more keywords
An Electrocatalytic Approach to the Radical Difunctionalization of Alkenes
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b01069
Abstract: Given its many distinct characteristics, electrochemistry represents an attractive approach to meet the prevailing trends in organic synthesis. In particular, electrocatalysis—a process that integrates electrochemistry and small-molecule catalysis—has the potential to substantially improve the scope… read more here.
Keywords: difunctionalization alkenes; catalysis; electrocatalytic approach; electrochemistry ... See more keywords
Catalytic Enantioselective Aminative Difunctionalization of Alkenes.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c00307
Abstract: Enantioselective difunctionalization of alkenes offers a straightforward means for the rapid construction of enantioenriched complex molecules. Despite the tremendous efforts devoted to this field, enantioselective aminative difunctionalization remains a challenge, particularly through an electrophilic addition… read more here.
Keywords: aminative difunctionalization; catalytic enantioselective; difunctionalization alkenes; difunctionalization ... See more keywords
Stereodivergent 1,3-difunctionalization of alkenes by charge relocation
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-023-06938-0
Abstract: Alkenes are indispensable feedstocks in chemistry. Functionalization at both carbons of the alkene—1,2-difunctionalization—is part of chemistry curricula worldwide1. Although difunctionalization at distal positions has been reported2–4, it typically relies on designer substrates featuring directing groups… read more here.
Keywords: charge relocation; chemistry; difunctionalization alkenes; difunctionalization ... See more keywords
Intermolecular 1,2-difunctionalization of alkenes.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Society reviews"
DOI: 10.1039/d5cs00670h
Abstract: Alkenes are an important class of organic compounds with a carbon-carbon double bond and a wide range of industrial and natural sources. The presence of π bonds provides the possibility for many forms of transformations.… read more here.
Keywords: difunctionalization olefins; chemistry; intermolecular difunctionalization; difunctionalization alkenes ... See more keywords
Transition-Metal-Catalyzed (Ni, Pd) Remote Difunctionalization of Alkenes via Chain-Walking Strategies
Sign Up to like & getrecommendations! Published in 2025 at "Synthesis"
DOI: 10.1055/a-2567-1329
Abstract: Alkenes are not only crucial feedstocks in the chemical industry but are also extensively present in natural products, pharmaceuticals, and organic functional materials. The direct difunctionalization of alkenes has emerged as a powerful and valuable… read more here.
Keywords: metal catalyzed; transition metal; catalyzed remote; difunctionalization alkenes ... See more keywords