Malaria Pigment Crystals: The Achilles′ Heel of the Malaria Parasite
Sign Up to like & getrecommendations! Published in 2021 at "Chemmedchem"
DOI: 10.1002/cmdc.202000895
Abstract: The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the malaria parasite, is reviewed as an antimalarial drug target. We first focus on the in‐vivo formation of hemozoin. A model is… read more here.
Keywords: malaria parasite; digestive vacuole; crystals achilles; hemozoin ... See more keywords
Plasmodium's bottomless pit: properties and functions of the malaria parasite's digestive vacuole.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in parasitology"
DOI: 10.1016/j.pt.2022.02.010
Abstract: During intraerythrocytic growth, the human malaria parasite Plasmodium falciparum degrades up to 80% of the host cell's hemoglobin inside an acidified organelle called the digestive vacuole (DV). Here, the globin chains are broken down by… read more here.
Keywords: digestive vacuole; malaria parasite; plasmodium bottomless; bottomless pit ... See more keywords
Imaging flow cytometry for the screening of compounds that disrupt the Plasmodium falciparum digestive vacuole.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.07.002
Abstract: Malaria, despite being one of the world's oldest infectious diseases, remains difficult to eradicate because the parasite is rapidly developing resistance to frontline chemotherapies. Previous studies have shown that the parasite exhibits features resembling programmed… read more here.
Keywords: digestive vacuole; screening compounds; imaging flow; cytometry screening ... See more keywords
Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3000376
Abstract: Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in… read more here.
Keywords: malaria parasite; death; digestive vacuole; disruption ... See more keywords