Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.12.004
Abstract: Here, we investigate the origin and nature of blastema cells that regenerate the adult murine digit tip. We show that Pdgfra-expressing mesenchymal cells in uninjured digits establish the regenerative blastema and are essential for regeneration.… read more here.
Keywords: digit; blastema; regeneration; digit tip ... See more keywords
Extracellular vesicles derived from Msh homeobox 1 (Msx1)-overexpressing mesenchymal stem cells improve digit tip regeneration in an amputee mice model
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DOI: 10.1038/s41598-024-72647-x
Abstract: In adult mammals, limb regeneration is limited by the absence of blastemal cells (BCs) and the lack of the regenerative signaling cascade. The utilization of transgenic cells circumvents the limitations associated with the absence of… read more here.
Keywords: extracellular vesicles; blcs evs; tip regeneration; msx1 ... See more keywords
Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells International"
DOI: 10.1155/2019/9619080
Abstract: Over the past several decades there has been a profound increase in the understanding of tissue regeneration, driven largely by the observance of the tremendous regenerative capacity in lower order life forms, such as hydra… read more here.
Keywords: medicine; treatment; digit tip; tip injuries ... See more keywords