Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects
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DOI: 10.1002/cpdd.280
Abstract: This article summarizes 4 phase 1 trials that explored interactions between the novel, triazole antifungal isavuconazole and substrates of the drug transporters breast cancer resistance protein (BCRP), multidrug and toxin extrusion protein‐1 (MATE1), organic anion… read more here.
Keywords: digoxin; atorvastatin digoxin; digoxin metformin; drug ... See more keywords
Repurposing of digoxin in pain and inflammation: An evidence‐based study
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DOI: 10.1002/ddr.21935
Abstract: In recent years, the drug repositioning strategy has gained considerable attention in the drug discovery process that involves establishing new therapeutic uses of already known drugs. In line with this, we have identified digoxin a… read more here.
Keywords: inflammation; digoxin pain; repurposing digoxin; digoxin ... See more keywords
Value of digoxin in patients with heart failure: new pieces to the puzzle
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1200
Abstract: Heart failure (HF) remains a large medical problem with an unacceptably high morbidity and mortality despite optimal medical and device treatment.1 Digoxin is the oldest drug in cardiovascular medicine, and in the most recent HF… read more here.
Keywords: trial; digoxin; heart; cardiology ... See more keywords
Clinical outcomes with digoxin vs. beta‐blocker for heart rate control in permanent atrial fibrillation with heart failure
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DOI: 10.1002/ejhf.2292
Abstract: Since the DIG study,1 which demonstrated that whilst digoxin reduced hospitalization for heart failure (HF), there was no significant overall effect on mortality, the place of digoxin in treating HF has steadily declined over recent… read more here.
Keywords: digoxin; heart; beta blocker; heart failure ... See more keywords
Development of a new ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the determination of digoxin and digitoxin in plasma: Comparison with a clinical immunoassay
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DOI: 10.1002/elps.202100290
Abstract: Cardiac glycosides digoxin and digitoxin are used in therapy for the treatment of congestive heart failure. Moreover, these compounds can be responsible for intoxication cases caused by fortuitous ingestion of leaves of Digitalis. Due to… read more here.
Keywords: digoxin; method determination; digoxin digitoxin; plasma ... See more keywords
[Cardiogenic shock following yew needle poisoning : Digoxin immune fab, va-ECMO and albumin dialysis for the treatment of a suicidal yew leaf poisoning].
Sign Up to like & getrecommendations! Published in 2021 at "Der Anaesthesist"
DOI: 10.1007/s00101-021-01048-w
Abstract: We present the case of a 46-year-old male who developed refractory bradycardia with cardiogenic shock after attempting suicide by ingestion of yew leaves. Due to delayed availability of the Digoxin immune fab, a va-ECMO was established… read more here.
Keywords: digoxin; yew; ecmo; immune fab ... See more keywords
Trends in Discharge Prescription of Digoxin After Norwood Operation: An Analysis of Data from the Pediatric Health Information System (PHIS) Database
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DOI: 10.1007/s00246-021-02543-y
Abstract: Quality improvement efforts have focused on reducing interstage mortality for infants with hypoplastic left heart syndrome (HLHS). In 1/2016, two publications reported that use of digoxin was associated with reduced interstage mortality. The degree to… read more here.
Keywords: digoxin; pediatric health; receiving digoxin; norwood operation ... See more keywords
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects
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DOI: 10.1007/s12325-017-0601-0
Abstract: IntroductionObeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug–drug interaction effect of OCA on metabolic CYP450 enzymes and… read more here.
Keywords: dextromethorphan; digoxin; rosuvastatin; warfarin ... See more keywords
Clinical Use of Digitalis: A State of the Art Review
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DOI: 10.1007/s40256-018-0292-1
Abstract: The history of digitalis is rich and interesting, with the first use usually attributed to William Withering and his study on the foxglove published in 1785. However, some knowledge of plants with digitalis-like effects used… read more here.
Keywords: digoxin; digitalis; use; rate control ... See more keywords
Association Between Digoxin Use and Adverse Outcomes Among Patients in the Chinese Atrial Fibrillation Registry
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DOI: 10.1007/s40256-019-00350-8
Abstract: IntroductionDigoxin is widely used in patients with atrial fibrillation (AF), but its association with adverse outcomes remains controversial.ObjectiveWe aimed to assess the association between digoxin and adverse outcomes in Chinese patients with AF.MethodsWe used data… read more here.
Keywords: atrial fibrillation; digoxin use; digoxin; adverse outcomes ... See more keywords
Outcomes in Patients on Digoxin Following LVAD Implantation
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DOI: 10.1016/j.cardfail.2019.07.506
Abstract: Introduction Digoxin use within the heart failure population remains controversial, as studies have suggested increased arrhythmia risk and lower survival. Despite decades of use in heart failure, little is known regarding digoxin utilization post-left ventricular… read more here.
Keywords: following lvad; digoxin; digoxin use; failure ... See more keywords