Synthesis and hetero-Diels-Alder reactions of enantiomerically pure dihydro-1H-azepines.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04413j
Abstract: Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence of K2CO3 gives in good yields 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines. These undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles and arylation/alkenylation under Suzuki conditions. read more here.
Keywords: diels alder; dihydro azepines; hetero diels; synthesis hetero ... See more keywords