Synthesis of New Derivatives of 4-(4,7,7-Trimethyl-7,8-dihydro-6H-benzo [b]pyrimido[5,4-e][1,4]thiazin-2-yl)morpholine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2556
Abstract: Cyclocondensation of 5-amino-6-methyl-2-morpholinopyrimidine-4-thiol (1) and 2-bromo-5,5-dimethylcyclohexane-1,3-dione (2) under mild reaction condition afforded 4,7,7-trimethyl-2-morpholino-7,8-dihydro-5H-benzo[b]pyrimido[5,4-e][1,4]thiazin-9(6H)-one (3). The 1H and 13C NMR data of compound (3) are demonstrated that this compound exists primarily in the enamino ketone form.… read more here.
Keywords: benzo pyrimido; trimethyl dihydro; pyrimido thiazin; dihydro benzo ... See more keywords
Carbon-based leaving group capability of Meldrum’s acid in substitution reactions: a new strategy toward the synthesis of 4-phenyl-3, 4-dihydro-2H-benzo[g]chromene-2, 5, 10-triones
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1129-6
Abstract: An efficient and straightforward method for the synthesis of new 5,5′-(2-benzylidenemalonyl)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives by the reaction of Meldrum’s acid and aldehydes under mild reaction conditions is reported. Furthermore, the leaving group potency of Meldrum’s acid molecules… read more here.
Keywords: leaving group; meldrum acid; toward synthesis; synthesis ... See more keywords
Synthesis and structure activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00596
Abstract: Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastrointestinal cancers, including esophageal, gastric, colorectal and pancreatic cancers. DCLK1 is also used as a marker of tuft cells, which regulate Type II… read more here.
Keywords: activity relationships; benzo pyrimido; kinase; structure activity ... See more keywords
In(OTf)3-Catalyzed Synthesis of 2,3-Dihydro-1H-benzo[e]indoles and 2,3-Dihydrobenzofurans via [3 + 2] Annulation.
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DOI: 10.1021/acs.orglett.0c02729
Abstract: An In(OTf)3-catalyzed intermolecular [3 + 2] annulation for the synthesis of 2,3-dihydro-1H-benzo[e]indoles and 2,3-dihydrobenzofurans from readily available substrates has been achieved. This approach takes advantage of oxetane and para-quinone methide as important functional units in… read more here.
Keywords: indoles dihydrobenzofurans; otf catalyzed; annulation; benzo indoles ... See more keywords
Temperature Tunable Synthesis of Tetrahydro-4H-pyrrolo[3,2-c]quinolin-4-ones and Dihydro-1H-benzo[b]azepines from 2-Aminobenzonitriles and Donor-Acceptor Cyclopropanes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03674
Abstract: Tetrahydro-4H-pyrrolo[3,2-c]quinolin-4-ones and dihydro-1H-benzo[b]azepines are efficiently synthesized from 2-aminobenzonitriles and donor-acceptor cyclopropanes mediated by SnCl4 in moderate to good yields. The reaction involves the initial ring opening of a cyclopropane ring due to activation by SnCl4… read more here.
Keywords: tetrahydro pyrrolo; ones dihydro; benzo azepines; dihydro benzo ... See more keywords
Efficient Synthesis of 7,8-Dihydro-6H-benzo[c]chromen-6-one Derivatives by Base-Mediated Chemoselective Annulation of Alkylidene Malononitriles with α,β-Unsaturated Coumarins
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DOI: 10.1055/s-0040-1706012
Abstract: An efficient and chemoselective synthesis of biologically valuable 7,8-dihydro-6H-benzo[c]chromen-6-ones is described. In this method, neither a metal catalyst nor expensive starting materials are needed, and the products can be purified by simple filtration and washing… read more here.
Keywords: benzo chromen; dihydro benzo; efficient synthesis;
New method for the synthesis of 4-aryl-3,4-dihydro-2H-benzo[g]chromene-2,5,10-triones
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DOI: 10.1080/00397911.2019.1646286
Abstract: Abstract We report herein a new method for the synthesis of 4-aryl-3,4-dihydro-2H-benzo[g]chromene-2,5,10-triones 4 that proceeds in good yields (74–86%) and mild reaction conditions between readily available 2-amino-4-aryl-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromene-3-carbonitriles 1, and formic acid (88%), at reflux for… read more here.
Keywords: benzo chromene; aryl; dihydro benzo;
2-[(4-Chlorophenyl)selanyl]-3,4-dihydro-2H-benzo[h]chromene-5,6-dione: crystal structure and Hirshfeld analysis
Sign Up to like & getrecommendations! Published in 2017 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989017007605
Abstract: A step-like conformation about the pyranyl ring is found for the molecular structure of the title compound. The three-dimensional packing is sustained by π–π, C—Cl⋯π and C—H⋯O interactions. read more here.
Keywords: selanyl dihydro; chromene dione; benzo chromene; chlorophenyl selanyl ... See more keywords
Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties
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DOI: 10.3390/molecules27227878
Abstract: Ten new differently substituted 3-benzyl-5-aryl-3,5-dihydro-4H-benzo[6,7]chromeno[2,3-d]pyrimidin-4,6,11-triones 3 were synthesized by a simple and cost-efficient procedure in a one-pot, three-component reaction from readily available ethyl 2-amino-4-aryl-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromene-3-carboxylates, benzylamine and triethyl orthoformate under solvent- and catalyst-free conditions. All the… read more here.
Keywords: dihydro benzo; colorectal cancer; activity; antiproliferative activity ... See more keywords
Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3+ + 2]-cycloaddition/rearrangement reactions
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.155
Abstract: Two new series of tricyclic heterocycles, namely 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepinium salts 10 and the related neutral, free bases 13 were synthesized from 4-acetoxy-1-acetyl-4-phenylazo-1,2,3,4-tetrahydroquinolines 8 and nitriles 9 in the presence of aluminium chloride by the [3+ +… read more here.
Keywords: synthesis new; new tricyclic; benzo triazolo; dihydro benzo ... See more keywords